Varier Krishnapriya M, Dhandapani Hemavathi, Liu Wuling, Song Jialei, Wang Chunlin, Hu Anling, Ben-David Yaacov, Shen Xiangchun, Li Yanmei, Gajendran Babu
State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, Guizhou Province, People's Republic of China.
The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences, Guiyang, 550014, Guizhou Province, People's Republic of China.
J Exp Clin Cancer Res. 2021 Jul 24;40(1):242. doi: 10.1186/s13046-021-01997-5.
Immunotherapeutic treatments are gaining attention due to their effective anti-tumor response. Particularly, the revolution of immune checkpoint inhibitors (ICIs) produces promising outcomes for various cancer types. However, the usage of immunotherapy is limited due to its low response rate, suggesting that tumor cells escape the immune surveillance. Rapid advances in transcriptomic profiling have led to recognize immune-related long non-coding RNAs (LncRNAs), as regulators of immune cell-specific gene expression that mediates immune stimulatory as well as suppression of immune response, indicating LncRNAs as targets to improve the efficacy of immunotherapy against tumours. Moreover, the immune-related LncRNAs acting as epigenetic modifiers are also under deep investigation. Thus, herein, is a summarised knowledge of LncRNAs and their regulation in the adaptive and innate immune system, considering their importance in autophagy and predicting putative immunotherapeutic responses.
免疫治疗因其有效的抗肿瘤反应而受到关注。特别是，免疫检查点抑制剂（ICI）的革命为各种癌症类型带来了有希望的结果。然而，免疫疗法的使用因其低反应率而受到限制，这表明肿瘤细胞逃避了免疫监视。转录组分析的快速进展已导致识别出免疫相关的长链非编码RNA（LncRNA），它们作为免疫细胞特异性基因表达的调节因子，介导免疫刺激以及免疫反应的抑制，这表明LncRNA可作为提高肿瘤免疫治疗疗效的靶点。此外，作为表观遗传修饰因子的免疫相关LncRNA也在深入研究中。因此，本文总结了LncRNA及其在适应性和先天性免疫系统中的调节作用，同时考虑到它们在自噬中的重要性以及预测可能的免疫治疗反应。
