1st Clinical Military Hospital with Outpatient Clinic, Lublin, Poland.
Biological Threats Identification and Countermeasure Centre, Military Institute of Hygiene and Epidemiology, Warsaw, Poland.
Ann Agric Environ Med. 2021 Dec 29;28(4):541-550. doi: 10.26444/aaem/143035. Epub 2021 Oct 22.
COVID-19 is a human infectious disease manifested by acute respiratory syndrome. On 30 January, 2020, the Word Heath Organization (WHO) declared a COVID-19 pandemic. The purpose of this article is to review publications on the search for substances that show inhibitory activity against SARS-CoV-2 infectivity, paying particular attention to the effect on different stages of the life cycle of the virus.
The review was based on an analysis of the latest available scientific literature and international databases. The data collected relate to the years 2020-2021.
Extremely intensive research is underway to find compounds that inhibit infection with the SARS-CoV-2 virus. Promising areas of research among the many current endeavours are antiviral compounds that stimulate the immune system, counter proliferation or affect individual viral replication cycles. These include, among others, interferons, monoclonal antibodies, natural compounds, peptides, aptamers, metal salts, and anti-inflammatory agents, inhibitors of viral enzymem, such as the RNA-dependent RNA polymerase. Preparations that help the body to combat the effects of infection have also assumed much importance.
The ongoing research is focused on the development of new antiviral agents, as well as the use of the existing drugs on the market. The results of clinical trials are promising and give hope for the development of effective therapies against SARS-CoV-2 and emerging variants of this virus.
COVID-19 是一种表现为急性呼吸系统综合征的人类传染病。2020 年 1 月 30 日，世界卫生组织（WHO）宣布 COVID-19 大流行。本文旨在综述针对具有抑制 SARS-CoV-2 感染性的物质的研究出版物，特别关注对病毒生命周期不同阶段的影响。
检索方法：本综述基于对最新可用科学文献和国际数据库的分析。收集的数据与 2020-2021 年相关。
现有知识状况简述：目前正在进行极其密集的研究，以寻找抑制 SARS-CoV-2 病毒感染的化合物。在目前众多努力中，有前景的研究领域包括刺激免疫系统、抑制增殖或影响单个病毒复制周期的抗病毒化合物。其中包括干扰素、单克隆抗体、天然化合物、肽、适体、金属盐和抗炎剂、病毒酶抑制剂，如 RNA 依赖性 RNA 聚合酶。有助于机体对抗感染影响的制剂也变得非常重要。
结论：目前的研究集中于开发新的抗病毒药物，以及使用现有市场上的药物。临床试验的结果令人鼓舞，为开发针对 SARS-CoV-2 及其新型变异株的有效疗法带来了希望。
