一名非地方性伯基特型急性淋巴细胞白血病患儿的细胞系中出现复杂易位t(8;12;14) 。
Complex translocation t(8;12;14) in a cell line derived from a child with nonendemic Burkitt-type acute lymphoblastic leukemia.
作者信息
Nacheva E, Fischer P, Karpas A, Sherrington P, Hayhoe F G, Manolov G, Manolova Y, Ferstl G, Haas O, Gadner H
出版信息
Cancer Genet Cytogenet. 1987 Sep;28(1):145-53. doi: 10.1016/0165-4608(87)90364-5.
PMID:3496952
Abstract
A cell line is described with a typical Burkitt lymphoma (BL) marker 14q+ due to the classical reciprocal translocation between chromosome #8 and #14 with breakpoints at 8q24.1 and 14q32.3. In addition, an interstitial piece from the long arm of 12(q24.1-q24.3) is inserted at the site of the exchange on chromosome #8, proximal to 14q32.3.
摘要
描述了一种细胞系，其具有典型的伯基特淋巴瘤（BL）标志物14q+，这是由于8号染色体与14号染色体之间发生经典的相互易位，断点位于8q24.1和14q32.3。此外，12号染色体长臂（q24.1-q24.3）的一段中间片段插入到8号染色体上交换位点处，靠近14q32.3。
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