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Co-condensation between transcription factor and coactivator p300 modulates transcriptional bursting kinetics.转录因子和共激活因子 p300 的共凝聚调节转录爆发动力学。
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WAPL maintains a cohesin loading cycle to preserve cell-type-specific distal gene regulation.WAPL 维持着黏连蛋白加载循环以维持细胞类型特异性的远端基因调控。
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动态单分子成像揭示的启动子-增强子通讯机制的新见解。

New insights into promoter-enhancer communication mechanisms revealed by dynamic single-molecule imaging.

机构信息

Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, U.S.A.

出版信息

Biochem Soc Trans. 2021 Jun 30;49(3):1299-1309. doi: 10.1042/BST20200963.

DOI:10.1042/BST20200963
PMID:34060610
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8325597/
Abstract

Establishing cell-type-specific gene expression programs relies on the action of distal enhancers, cis-regulatory elements that can activate target genes over large genomic distances - up to Mega-bases away. How distal enhancers physically relay regulatory information to target promoters has remained a mystery. Here, we review the latest developments and insights into promoter-enhancer communication mechanisms revealed by live-cell, real-time single-molecule imaging approaches.

摘要

建立细胞类型特异性基因表达程序依赖于远端增强子的作用，这些顺式调控元件可以在很大的基因组距离上激活靶基因 - 高达 Mega-bases 远。远端增强子如何将调控信息物理传递给靶启动子仍然是一个谜。在这里，我们综述了通过活细胞实时单分子成像方法揭示的启动子-增强子通讯机制的最新进展和见解。