Department of Radiology, Neuroimaging and Neurointervention, Stanford University School of Medicine, Stanford, CA, USA.
Divisions of Emergency Radiology and Neuroradiology, Northwell Health, North Shore University Hospital, Manhasset, NY, USA.
Yale J Biol Med. 2021 Dec 29;94(4):599-602. eCollection 2021 Dec.
A 67-year-old male presented to the hospital for lower back pain and left lower extremity radiculopathy. Although the patient was afebrile and white blood cell count was normal, MRI was concerning for discitis/osteomyelitis at L4-L5. Subsequently, the patient developed a right knee joint effusion and underwent an arthrocentesis that was notable for the presence of urate crystals. A systemic urate crystal arthropathy was proposed as a potential etiology for the patient's back pain and radiculopathy. Dual energy CT of the lumbar spine was performed, a technique which determines material composition by comparing the photon attenuation of the substance from two different x-ray energy levels. Results revealed the presence of monosodium urate crystals in the intervertebral discs. This technique is proposed as a noninvasive way to evaluate for gout in atypical locations or those difficult to sample and may replace an invasive intervertebral disc/endplate aspiration and/or biopsy. Dual energy CT should be considered in patients with elevated serum uric acid and concern for spinal involvement of gout.
一位 67 岁男性因腰痛和左下肢神经根病变到医院就诊。尽管患者无发热,白细胞计数正常,但 MRI 检查提示 L4-L5 椎间盘炎/骨髓炎。随后,患者出现右膝关节积液,并进行了关节穿刺,关节液中可见尿酸盐晶体。因此提出全身性尿酸盐晶体关节病可能是患者腰痛和神经根病变的潜在病因。对腰椎进行了双能 CT 检查,该技术通过比较物质在两种不同 X 射线能量水平下的光子衰减来确定物质的组成。结果显示椎间盘内存在单钠尿酸盐晶体。该技术被提议作为一种非侵入性方法,用于评估在非典型部位或难以取样的部位发生的痛风,并且可能替代有创的椎间盘/终板抽吸和/或活检。对于血清尿酸升高且怀疑痛风累及脊柱的患者,应考虑使用双能 CT。