School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411,-India.
Recent Adv Drug Deliv Formul. 2022;16(1):45-54. doi: 10.2174/2667387816666211231103759.
Pharmaceutical oral dosage forms are tremendously preferred by both consumers as well as pharmaceutical manufacturers owing to the plethora of benefits they offer. Lozenges (LZs) are one of the dosage forms that provide a palatable means of drug administration and have great importance with respect to their pharmaceutical applications. LZs offer additional benefits to pediatric and geriatric patients, along with people having problems associated with the gastro-intestinal tract. Dysphagia is a common problem faced by all age groups, which gives rise to the need for LZs. Moreover, the foremost merit presented by the medicated LZs includes its augmented retention time in the oral cavity that results in an enhanced bioavailability for buccal or upper gastro-intestinal disorders. Further, LZs can also be used to bypass the first-pass effect. The present review covers various aspects of LZs such as formulation, manufacturing techniques, evaluation parameters, marketed products, patents, and a compilation of research work that has been done on lozenges as a delivery system.
由于其提供的众多益处，药物口服剂型深受消费者和制药商的青睐。口含片（LZ）是一种提供可口的药物给药方式的剂型，并且在其药物应用方面具有重要意义。LZ 为儿科和老年患者以及与胃肠道问题有关的人群提供了额外的益处。吞咽困难是所有年龄段都面临的常见问题，这就需要使用 LZ。此外，经药物处理的 LZ 的最大优点包括其在口腔中的滞留时间延长，从而提高了口腔或上胃肠道疾病的生物利用度。此外，LZ 还可用于绕过首过效应。本综述涵盖了 LZ 的各个方面，例如配方、制造技术、评估参数、市售产品、专利以及作为给药系统的 LZ 的研究工作汇编。
