Department of Ophthalmology, Elazig Fethi Sekin City Hospital, Health Science University, Elazig Campus, Elazig, Turkey.
Department of Medical Biochemistry and Clinical Biochemistry, (Firat Hormones Research Group), School of Medicine, Firat University, Elazig, Turkey.
Peptides. 2022 Apr;150:170728. doi: 10.1016/j.peptides.2021.170728. Epub 2021 Dec 28.
Peptide phoenixin (PNX), endocan (EDC), and spexin (SPX) are associated with diabetes. Therefore, the purpose of this study was to investigate the levels of PNX, EDC and SPX in the blood and aqueous humor (AH) of patient with type 2 diabetes with and without DRP and cataract. 30 type 2 diabetes patients with cataract (DM + C), 30 DRP patient with cataract (DRP + C), 30 non-diabetic patient with only cataract and 30 control participants were enrolled into this study. PNX, EDC, and SPX were measured in blood and AH by ELISA. In patients with DRP + C, the levels of PNX and EDC were significantly higher in both AH and blood samples compared with the group of patients without DRP + C (<0.05). Also, in patients with DM + C, the levels of PNX and EDC were higher in both AH and blood samples compared with the group of patients without DM + C. However, in patients with DRP + C, the levels of SPX were significantly lower in both AH and blood samples compared with the group of patients without DRP + C (<0.05). Also, in patients with DM + C, the levels of SPX were also lower in both AH and blood samples compared with the group of patients without DM + C. These findings suggest that increased PNX, EDC, and decreased SPX amounts in blood and AH of DM + C and DRP + C groups when compared with control and cataract groups show that they might have a role in the pathophysiology of DM + C, especially in the DRP + C.
肽凤凰素（PNX）、内皮细胞（EDC）和 Spexin（SPX）与糖尿病有关。因此，本研究的目的是研究 2 型糖尿病伴或不伴 DRP 和白内障患者血液和房水中 PNX、EDC 和 SPX 的水平。本研究纳入了 30 例伴白内障的 2 型糖尿病患者（DM + C）、30 例伴白内障的 DRP 患者（DRP + C）、30 例单纯白内障且无糖尿病的患者和 30 名对照参与者。通过 ELISA 法测量血液和房水中的 PNX、EDC 和 SPX。在 DRP + C 患者中，AH 和血液样本中 PNX 和 EDC 的水平明显高于无 DRP + C 的患者组（<0.05）。此外，在 DM + C 患者中，AH 和血液样本中 PNX 和 EDC 的水平均高于无 DM + C 的患者组。然而，在 DRP + C 患者中，AH 和血液样本中 SPX 的水平明显低于无 DRP + C 的患者组（<0.05）。此外，在 DM + C 患者中，AH 和血液样本中 SPX 的水平也低于无 DM + C 的患者组。这些发现表明，与对照组和白内障组相比，DM + C 和 DRP + C 组血液和房水中 PNX、EDC 的增加和 SPX 含量的减少可能在 DM + C 的病理生理学中起作用，尤其是在 DRP + C 中。
