恶性脑胶质瘤放化疗前睡眠问题的危险因素。
Risk Factors for Sleep Problems Prior to Radiochemotherapy for Malignant Gliomas.
机构信息
Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.
Department of Hematology and Oncology, University of Lübeck, Lübeck, Germany.
出版信息
In Vivo. 2022 Jan-Feb;36(1):325-329. doi: 10.21873/invivo.12705.
BACKGROUND/AIM: Many patients with malignant gliomas are scheduled for radiochemotherapy, which may cause emotional distress associated with sleep problems. This study aimed to determine the prevalence of such sleep problems in these patients and identify risk factors.
PATIENTS AND METHODS
Fifty-seven patients scheduled for radiochemotherapy for grade II-IV gliomas were retrospectively investigated for pre-treatment sleep problems. Fifteen characteristics were evaluated including temporal relation to COVID-19 pandemic, age, gender, performance status, comorbidity, (family) history of malignancies, distress score, emotional problems, physical problems, practical problems, involved sites, glioma grade, upfront surgery, and corticosteroids.
RESULTS
Nineteen patients stated pre-treatment sleep problems (prevalence=66.7%). Significant associations with sleep problems were found for female gender (p=0.023), presence of emotional problems (p=0.006), and ≥4 physical problems (p<0.001). A trend was found for distress scores ≥5 (p=0.077).
CONCLUSION
The prevalence of sleep problems was high. Risk factors were determined that can be used to identify patients who likely benefit from psychological support.
背景/目的：许多恶性胶质瘤患者需要接受放化疗，这可能导致与睡眠问题相关的情绪困扰。本研究旨在确定这些患者中睡眠问题的发生率，并确定其危险因素。
患者和方法
回顾性调查了 57 例拟行 II-IV 级胶质瘤放化疗的患者的治疗前睡眠问题。评估了 15 个特征，包括与 COVID-19 大流行的时间关系、年龄、性别、表现状态、合并症、（家族）恶性肿瘤史、困扰评分、情绪问题、身体问题、实际问题、受累部位、胶质瘤分级、初始手术和皮质类固醇。
结果
19 例患者报告存在治疗前睡眠问题（发生率=66.7%）。与睡眠问题显著相关的因素包括女性性别（p=0.023）、存在情绪问题（p=0.006）和≥4 个身体问题（p<0.001）。困扰评分≥5 也有趋势（p=0.077）。
结论
睡眠问题的发生率较高。确定了一些危险因素，可用于识别可能受益于心理支持的患者。
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