Department of Radiation Oncology, University of Lübeck, Lübeck, Germany;
Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.
In Vivo. 2021 Jul-Aug;35(4):2253-2260. doi: 10.21873/invivo.12498.
BACKGROUND/AIM: The anticipation of radiotherapy can cause distress and sleep disorders, which may be aggravated by the COVID-19 pandemic. This study investigated sleep disorders in a large cohort of patients with breast cancer before and during the pandemic.
Twenty-three characteristics were retrospectively analyzed for associations with pre-radiotherapy sleep disorders in 338 patients. Moreover, 163 patients presenting before and 175 patients presenting during the COVID-19 pandemic were compared for sleep disorders.
Sleep disorders were significantly associated with age ≤60 years (p=0.006); high distress score (p<0.0001); more emotional (p<0.0001), physical (p<0.0001) or practical (p<0.0001) problems; psycho-oncological need (p<0.0001); invasive cancer (p=0.003); chemotherapy (p<0.001); and hormonal therapy (p=0.006). Sleep disorders were similarly common in both groups (prior to vs. during the pandemic: 40% vs. 45%, p=0.38).
Although additional significant risk factors for sleep disorders were identified, the COVID-19 pandemic appeared to have no significant impact on sleep disorders in patients scheduled for irradiation of breast cancer.
背景/目的：放疗前的预期会引起痛苦和睡眠障碍，而 COVID-19 大流行可能会使这些问题恶化。本研究调查了大样本乳腺癌患者在大流行前和大流行期间的睡眠障碍情况。
对 338 例患者的 23 项特征进行回顾性分析，以研究与放疗前睡眠障碍的相关性。此外，对 163 例在 COVID-19 大流行前就诊的患者和 175 例在大流行期间就诊的患者进行了睡眠障碍比较。
睡眠障碍与年龄≤60 岁（p=0.006）；高痛苦评分（p<0.0001）；更多的情绪（p<0.0001）、身体（p<0.0001）或实际（p<0.0001）问题；心理肿瘤学需求（p<0.0001）；浸润性癌症（p=0.003）；化疗（p<0.001）；和激素治疗（p=0.006）显著相关。两组的睡眠障碍发生率相似（大流行前 vs. 大流行期间：40% vs. 45%，p=0.38）。
尽管确定了其他导致睡眠障碍的显著危险因素，但 COVID-19 大流行似乎对计划接受乳腺癌放疗的患者的睡眠障碍没有显著影响。
