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利用自然语言处理从进食障碍患者的临床样本中提取自伤和自杀倾向数据:一项回顾性队列研究。

Using natural language processing to extract self-harm and suicidality data from a clinical sample of patients with eating disorders: a retrospective cohort study.

机构信息

South London & Maudsley, NHS Foundation Trust, London, UK

Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK.

出版信息

BMJ Open. 2021 Dec 31;11(12):e053808. doi: 10.1136/bmjopen-2021-053808.

Abstract

OBJECTIVES

The objective of this study was to determine risk factors for those diagnosed with eating disorders who report self-harm and suicidality.

DESIGN AND SETTING

This study was a retrospective cohort study within a secondary mental health service, South London and Maudsley National Health Service Trust.

PARTICIPANTS

All diagnosed with an F50 diagnosis of eating disorder from January 2009 to September 2019 were included.

INTERVENTION AND MEASURES

Electronic health records (EHRs) for these patients were extracted and two natural language processing tools were used to determine documentation of self-harm and suicidality in their clinical notes. These tools were validated manually for attribute agreement scores within this study.

RESULTS

The attribute agreements for precision of positive mentions of self-harm were 0.96 and for suicidality were 0.80; this demonstrates a 'near perfect' and 'strong' agreement and highlights the reliability of the tools in identifying the EHRs reporting self-harm or suicidality. There were 7434 patients with EHRs available and diagnosed with eating disorders included in the study from the dates January 2007 to September 2019. Of these, 4591 (61.8%) had a mention of self-harm within their records and 4764 (64.0%) had a mention of suicidality; 3899 (52.4%) had mentions of both. Patients reporting either self-harm or suicidality were more likely to have a diagnosis of anorexia nervosa (AN) (self-harm, AN OR=3.44, 95% CI 1.05 to 11.3, p=0.04; suicidality, AN OR=8.20, 95% CI 2.17 to 30.1; p=0.002). They were also more likely to have a diagnosis of borderline personality disorder (p≤0.001), bipolar disorder (p<0.001) or substance misuse disorder (p<0.001).

CONCLUSION

A high percentage of patients (>60%) diagnosed with eating disorders report either self-harm or suicidal thoughts. Relative to other eating disorders, those diagnosed with AN were more likely to report either self-harm or suicidal thoughts. Psychiatric comorbidity, in particular borderline personality disorder and substance misuse, was also associated with an increase risk in self-harm and suicidality. Therefore, risk assessment among patients diagnosed with eating disorders is crucial.

摘要

目的

本研究旨在确定报告自伤和自杀意念的被诊断为饮食障碍患者的风险因素。

设计和设置

这是一项在二级精神卫生服务机构南伦敦和莫兹利国民保健服务信托基金内进行的回顾性队列研究。

参与者

纳入了 2009 年 1 月至 2019 年 9 月期间被诊断为 F50 诊断的饮食障碍患者。

干预和措施

提取这些患者的电子健康记录(EHR),并使用两种自然语言处理工具来确定他们临床记录中自伤和自杀意念的文档记录。在这项研究中,手动验证了这些工具在属性一致性方面的准确性。

结果

自伤阳性提及的精确性的属性一致性为 0.96,自杀意念的属性一致性为 0.80;这表明存在“近乎完美”和“强烈”的一致性,并突出了这些工具在识别报告自伤或自杀意念的 EHR 方面的可靠性。共有 7434 名患者的 EHR 可用于从 2007 年 1 月至 2019 年 9 月的研究中。其中,4591 名(61.8%)的记录中有自伤记录,4764 名(64.0%)的记录中有自杀意念记录;3899 名(52.4%)同时记录了自伤和自杀意念。报告自伤或自杀意念的患者更有可能被诊断为神经性厌食症(AN)(自伤,AN OR=3.44,95%CI 1.05 至 11.3,p=0.04;自杀意念,AN OR=8.20,95%CI 2.17 至 30.1;p=0.002)。他们也更有可能被诊断为边缘型人格障碍(p≤0.001)、双相情感障碍(p<0.001)或物质使用障碍(p<0.001)。

结论

被诊断为饮食障碍的患者中有很大比例(>60%)报告了自伤或自杀念头。与其他饮食障碍相比,被诊断为 AN 的患者更有可能报告自伤或自杀念头。精神共病,特别是边缘型人格障碍和物质使用障碍,也与自伤和自杀风险的增加相关。因此,对被诊断为饮食障碍的患者进行风险评估至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83d6/8720985/a7e240355526/bmjopen-2021-053808f01.jpg

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