Gynaecology and Obstetrics, Centro Hospitalar de Entre o Douro e Vouga EPE, Santa Maria da Feira, Portugal
Gynaecology and Obstetrics, Centro Hospitalar de Entre o Douro e Vouga EPE, Santa Maria da Feira, Portugal.
BMJ Case Rep. 2021 Dec 31;14(12):e246797. doi: 10.1136/bcr-2021-246797.
A 26-year-old woman under immunosuppression with infliximab due to Crohn's disease was referred to the gynaecology emergency room with dispersed and coalescing vesicular lesions on the vulvar region extending to the right lower limb involving S2-S3 dermatome, associated with severe pain. Clinical history, physical examination and serological testing was consistent with herpes zoster infection. The patient was treated with valaciclovir for 14 days and cefradine for 7 days (due to the possibility of secondary bacterial infection). Significant symptomatic improvement was noted after 1 week. The 1-year follow-up was unremarkable. According to our knowledge and review of the literature, this is one of the few cases reported of vulvar herpes zoster, especially related to infliximab.
一位 26 岁女性因克罗恩病接受英夫利昔单抗免疫抑制治疗，因外阴区弥漫融合性水疱性皮损，累及右侧下肢 S2-S3 皮节，伴剧烈疼痛，就诊于妇科急诊。临床病史、体格检查和血清学检测均符合带状疱疹感染。患者接受伐昔洛韦治疗 14 天和头孢拉定治疗 7 天（因存在继发细菌感染的可能）。治疗 1 周后，患者症状显著改善。1 年随访无异常。据我们所知并结合文献复习，这是少数几例报告的外阴带状疱疹病例之一，特别是与英夫利昔单抗相关的病例。
