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利用木瓜乳胶原液对 SPIONs 进行涂层以实现染料去除和药物输送。

Utilization of Carica papaya latex on coating of SPIONs for dye removal and drug delivery.

机构信息

School of Bioscience, Faculty of Medicine, Bioscience and Nursing, MAHSA University, 42610, Jenjarom, Selangor, Malaysia.

Centre for Materials Engineering and Regenerative Medicine, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, 600073, India.

出版信息

Sci Rep. 2021 Dec 31;11(1):24511. doi: 10.1038/s41598-021-03328-2.

DOI:10.1038/s41598-021-03328-2
PMID:34972829
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8720089/
Abstract

Latex, a milky substance found in a variety of plants which is a natural source of biologically active compounds. In this study, Latex was collected from raw Carica papaya and was characterized using UV-Vis, FTIR and GC-MS analyses. Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) were synthesized, coated with C. papaya latex (PL-Sp) and characterized using UV-Vis, FT-IR, SEM-EDX, XRD, VSM and Zeta potential analyses. SPIONs and latex coated SPIONs (PL-Sp) were used in batch adsorption study for effective removal of Methylene blue (MB) dye, where (PL-Sp) removed MB dye effectively. Further the PL-Sp was used to produce a nanoconjugate loaded with curcumin and it was characterized using UV-Vis spectrophotometer, FT-IR, SEM-EDX, XRD, VSM and Zeta potential. It showed a sustained drug release pattern and also found to have good antibacterial and anticancer activity.

摘要

乳胶，一种存在于多种植物中的乳白色物质，是具有生物活性化合物的天然来源。在这项研究中，乳胶是从生木瓜中提取的，并通过 UV-Vis、FTIR 和 GC-MS 分析进行了表征。超顺磁氧化铁纳米粒子（SPIONs）被合成，并用木瓜乳胶（PL-Sp）进行了包覆，并通过 UV-Vis、FT-IR、SEM-EDX、XRD、VSM 和 Zeta 电位分析进行了表征。SPIONs 和乳胶包覆的 SPIONs（PL-Sp）被用于分批吸附研究，以有效去除亚甲蓝（MB）染料，其中（PL-Sp）有效地去除了 MB 染料。此外，PL-Sp 被用于制备负载姜黄素的纳米缀合物，并通过 UV-Vis 分光光度计、FT-IR、SEM-EDX、XRD、VSM 和 Zeta 电位进行了表征。它显示出持续的药物释放模式，并且还被发现具有良好的抗菌和抗癌活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e64/8720089/7ba1e679ff10/41598_2021_3328_Fig13_HTML.jpg
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