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免疫疗法的肺部毒性。

Pulmonary Toxicities of Immunotherapy.

机构信息

Thoracic/Head & Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

University of Texas MD Anderson Cancer Center, Houston, TX, USA.

出版信息

Adv Exp Med Biol. 2021;1342:357-375. doi: 10.1007/978-3-030-79308-1_14.

DOI:10.1007/978-3-030-79308-1_14
PMID:34972974
Abstract

Immune checkpoint inhibitors are a form of immunotherapy that are increasingly being used in a wide variety of cancers. Immune-related adverse events (irAEs) pose a major challenge in the treatment of cancer patients. Pneumonitis, the most common lung irAE, can cause significant disruptions in the treatment of cancer and may be life-threatening. The goal of this chapter is to instruct readers on the incidence and clinical manifestations of pneumonitis and to offer guidance in the evaluation and treatment of patients with pneumonitis.

摘要

免疫检查点抑制剂是一种免疫疗法,越来越多地用于多种癌症的治疗。免疫相关不良事件(irAEs)是癌症患者治疗的主要挑战。肺炎是最常见的肺部 irAE,可导致癌症治疗的重大中断,并可能危及生命。本章的目的是指导读者了解肺炎的发生率和临床表现,并为肺炎患者的评估和治疗提供指导。

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Pulmonary Toxicities of Immunotherapy.免疫疗法的肺部毒性。
Adv Exp Med Biol. 2021;1342:357-375. doi: 10.1007/978-3-030-79308-1_14.
2
Immune-Related Adverse Events: Pneumonitis.免疫相关不良反应:肺炎。
Adv Exp Med Biol. 2020;1244:255-269. doi: 10.1007/978-3-030-41008-7_13.
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Immune-Related Adverse Events: Pneumonitis.免疫相关不良反应:肺炎。
Adv Exp Med Biol. 2018;995:131-149. doi: 10.1007/978-3-030-02505-2_6.
4
The determinants of very severe immune-related adverse events associated with immune checkpoint inhibitors: A prospective study of the French REISAMIC registry.与免疫检查点抑制剂相关的极重度免疫相关不良事件的决定因素:法国 REISAMIC 注册前瞻性研究。
Eur J Cancer. 2021 Nov;158:217-224. doi: 10.1016/j.ejca.2021.08.048. Epub 2021 Oct 7.
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Immune-related adverse events on body CT in patients with small-cell lung cancer treated with immune-checkpoint inhibitors.免疫检查点抑制剂治疗小细胞肺癌患者的体 CT 免疫相关不良反应。
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[No hair loss, but colitis or pneumonitis: unique side effects of immune checkpoint inhibitors for cancer].[无脱发,但有结肠炎或肺炎:癌症免疫检查点抑制剂的独特副作用]
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Expected and non-expected immune-related adverse events detectable by CT.预期和非预期的免疫相关不良反应可通过 CT 检测到。
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[Clinical Diagnosis and Treatment Recommendations for the Pneumonitis Associated with Immune Checkpoint Inhibitor].[免疫检查点抑制剂相关肺炎的临床诊断与治疗建议]
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本文引用的文献

1
Distinct Immunophenotypes of T Cells in Bronchoalveolar Lavage Fluid From Leukemia Patients With Immune Checkpoint Inhibitors-Related Pulmonary Complications.白血病患者免疫检查点抑制剂相关肺部并发症支气管肺泡灌洗液中 T 细胞的不同免疫表型。
Front Immunol. 2021 Jan 21;11:590494. doi: 10.3389/fimmu.2020.590494. eCollection 2020.
2
Lessons to be Learnt from Real-World Studies on Immune-Related Adverse Events with Checkpoint Inhibitors: A Clinical Perspective from Pharmacovigilance.从免疫相关不良事件的真实世界研究中吸取的经验教训:药物警戒的临床视角。
Target Oncol. 2020 Aug;15(4):449-466. doi: 10.1007/s11523-020-00738-6.
3
免疫检查点抑制剂所致肺部毒性管理临床实践指南的系统评价:治疗建议质量及指南间管理策略差异
Clin Med Insights Oncol. 2023 Nov 8;17:11795549231203153. doi: 10.1177/11795549231203153. eCollection 2023.
Updated Analysis From KEYNOTE-189: Pembrolizumab or Placebo Plus Pemetrexed and Platinum for Previously Untreated Metastatic Nonsquamous Non-Small-Cell Lung Cancer.
KEYNOTE-189 更新分析:帕博利珠单抗或安慰剂联合培美曲塞和铂类化疗用于未经治疗的转移性非鳞状非小细胞肺癌。
J Clin Oncol. 2020 May 10;38(14):1505-1517. doi: 10.1200/JCO.19.03136. Epub 2020 Mar 9.
4
Immunotherapy-Induced Airway Disease: A New Pattern of Lung Toxicity of Immune Checkpoint Inhibitors.免疫治疗相关气道疾病:免疫检查点抑制剂肺毒性的一种新类型。
Respiration. 2020;99(2):181-186. doi: 10.1159/000504968. Epub 2020 Jan 8.
5
Transbronchial Cryobiopsy for the Diagnosis of Interstitial Lung Diseases: CHEST Guideline and Expert Panel Report.经支气管冷冻肺活检诊断间质性肺疾病:CHEST 指南和专家小组报告。
Chest. 2020 Apr;157(4):1030-1042. doi: 10.1016/j.chest.2019.10.048. Epub 2019 Nov 27.
6
Association of immune-related pneumonitis with the presence of preexisting interstitial lung disease in patients with non-small lung cancer receiving anti-programmed cell death 1 antibody.免疫相关性肺炎与非小细胞肺癌患者接受抗程序性死亡 1 抗体治疗时存在预先存在的间质性肺病的相关性。
Cancer Immunol Immunother. 2020 Jan;69(1):15-22. doi: 10.1007/s00262-019-02431-8. Epub 2019 Nov 19.
7
Diagnostic accuracy of transbronchial lung cryobiopsy for interstitial lung disease diagnosis (COLDICE): a prospective, comparative study.经支气管肺冷冻活检术诊断间质性肺疾病的诊断准确性(COLDICE):一项前瞻性、对比研究。
Lancet Respir Med. 2020 Feb;8(2):171-181. doi: 10.1016/S2213-2600(19)30342-X. Epub 2019 Sep 29.
8
The alveolar immune cell landscape is dysregulated in checkpoint inhibitor pneumonitis.肺泡免疫细胞图谱在检查点抑制剂性肺炎中失调。
J Clin Invest. 2019 Jul 16;129(10):4305-4315. doi: 10.1172/JCI128654.
9
Atezolizumab in combination with carboplatin plus nab-paclitaxel chemotherapy compared with chemotherapy alone as first-line treatment for metastatic non-squamous non-small-cell lung cancer (IMpower130): a multicentre, randomised, open-label, phase 3 trial.阿替利珠单抗联合卡铂加白蛋白紫杉醇化疗与单纯化疗一线治疗转移性非鳞状非小细胞肺癌(IMpower130):一项多中心、随机、开放标签、III 期临床试验。
Lancet Oncol. 2019 Jul;20(7):924-937. doi: 10.1016/S1470-2045(19)30167-6. Epub 2019 May 20.
10
Inhibitory Receptors and Pathways of Lymphocytes: The Role of PD-1 in Treg Development and Their Involvement in Autoimmunity Onset and Cancer Progression.抑制性受体和淋巴细胞途径:PD-1 在调节性 T 细胞发育中的作用及其在自身免疫起始和癌症进展中的参与。
Front Immunol. 2018 Oct 17;9:2374. doi: 10.3389/fimmu.2018.02374. eCollection 2018.