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免疫疗法的肺部毒性。

Pulmonary Toxicities of Immunotherapy.

机构信息

Thoracic/Head & Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

University of Texas MD Anderson Cancer Center, Houston, TX, USA.

出版信息

Adv Exp Med Biol. 2021;1342:357-375. doi: 10.1007/978-3-030-79308-1_14.

Abstract

Immune checkpoint inhibitors are a form of immunotherapy that are increasingly being used in a wide variety of cancers. Immune-related adverse events (irAEs) pose a major challenge in the treatment of cancer patients. Pneumonitis, the most common lung irAE, can cause significant disruptions in the treatment of cancer and may be life-threatening. The goal of this chapter is to instruct readers on the incidence and clinical manifestations of pneumonitis and to offer guidance in the evaluation and treatment of patients with pneumonitis.

摘要

免疫检查点抑制剂是一种免疫疗法,越来越多地用于多种癌症的治疗。免疫相关不良事件(irAEs)是癌症患者治疗的主要挑战。肺炎是最常见的肺部 irAE,可导致癌症治疗的重大中断,并可能危及生命。本章的目的是指导读者了解肺炎的发生率和临床表现,并为肺炎患者的评估和治疗提供指导。

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