Ray A, Hemady Z, Rocklin R E
N Engl Reg Allergy Proc. 1987 Mar-Apr;8(2):81-4. doi: 10.2500/108854187778994400.
Glucocorticoid-induced enhancement of polyclonal immunoglobulin production of the IgG, A, and M classes by human peripheral blood mononuclear cells has been shown to be dependent on regulatory T-cells. The following in vitro investigation demonstrated an enhancing effect of glucocorticoid on IgE production by mononuclear cells from atopic patients, but not by cells from non-atopic subjects. Augmentation was noted even in cell populations depleted of T cells and monocytes. These observations suggest that the corticosteroid acted directly on an IgE B cell at a late stage of differentiation that was no longer dependent on helper T-cells, although an additional effect on T-suppressor cells was not excluded.
糖皮质激素诱导人外周血单核细胞产生的IgG、A和M类多克隆免疫球蛋白增加已被证明依赖于调节性T细胞。以下体外研究表明，糖皮质激素对特应性患者单核细胞产生IgE有增强作用，而非特应性受试者的细胞则无此作用。即使在T细胞和单核细胞耗竭的细胞群体中也观察到了增强作用。这些观察结果表明，皮质类固醇在分化后期直接作用于IgE B细胞，该阶段不再依赖辅助性T细胞，尽管不排除对T抑制细胞有额外作用。
