Kanowith-Klein S, Saxon A
Int Arch Allergy Appl Immunol. 1986;80(1):33-8. doi: 10.1159/000234022.
Supernatants derived from T cells of donors with and without atopic disease were assessed to determine whether they could regulate ongoing IgE, IgG, or IgA synthesis of three different human B-cell lines. The results were compared with the ability of T-cell supernatants from the atopic donors to specifically induce IgE synthesis of nonatopic peripheral blood B lymphocytes (PBL-B cells). We found that, when tested on the B-cell lines, the T-cell supernatants from atopic donors doubled the IgE as well as the IgG and IgA synthesis. Although the T-cell supernatants from nonatopic donors had no effect on Ig synthesis of PBL-B cells or on the IgG of the IgG-secreting cell line, the supernatants doubled the IgE and moderately enhanced IgA synthesis of the IgE- and IgG-secreting cell lines. These results demonstrate that T-cell supernatants derived from atopic and nonatopic donors differ in their regulatory effects, not only on PBL-B cells, as had been shown previously by others, but also in their effects on ongoing Ig production.
对来自患特应性疾病和未患特应性疾病供体的T细胞产生的上清液进行评估，以确定它们是否能够调节三种不同人类B细胞系正在进行的IgE、IgG或IgA合成。将结果与来自特应性供体的T细胞上清液特异性诱导非特应性外周血B淋巴细胞（PBL - B细胞）合成IgE的能力进行比较。我们发现，在B细胞系上进行测试时，来自特应性供体的T细胞上清液使IgE以及IgG和IgA合成增加了一倍。虽然来自非特应性供体的T细胞上清液对PBL - B细胞的Ig合成或IgG分泌细胞系的IgG没有影响，但这些上清液使IgE和IgG分泌细胞系的IgE合成增加了一倍，并适度增强了IgA合成。这些结果表明，来自特应性和非特应性供体的T细胞上清液在调节作用上存在差异，不仅如其他人之前所表明的那样对PBL - B细胞有差异，而且在对正在进行的Ig产生的影响方面也存在差异。
