Sette A, Buus S, Colon S, Smith J A, Miles C, Grey H M
Nature. 1987;328(6129):395-9. doi: 10.1038/328395a0.
A detailed analysis of the residues within an immunogenic peptide that endow it with the capacity to interact with Ia and to be recognized by T cells is presented. Ia interacts with only a few of the peptide residues and overall exhibits a very broad specificity. Some residues appear to interact both with Ia and with T cells, leading to a model in which a peptide antigen is 'sandwiched' between Ia and the T-cell receptor.
本文对免疫原性肽内赋予其与Ia相互作用及被T细胞识别能力的残基进行了详细分析。Ia仅与少数肽残基相互作用，总体表现出非常宽泛的特异性。一些残基似乎既与Ia相互作用又与T细胞相互作用，从而形成了一种模型，即肽抗原“夹”在Ia和T细胞受体之间。
