Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Trends Neurosci. 2022 Apr;45(4):251-253. doi: 10.1016/j.tins.2021.12.001. Epub 2021 Dec 29.
In the gut, coordinated cell interactions regulate tissue repair and immunity. How enteric glial cells (EGCs) mediate these processes remained elusive. In a recent paper, Progatzky et al. demonstrate that EGCs interact with immune and mesothelial cells under homeostasis and helminth infection, revealing an indispensable role of an interferon-γ (IFNγ)-EGC-CXCL10 axis in tissue repair.
在肠道中，细胞间的协调相互作用调节组织修复和免疫。肠胶质细胞 (EGC) 如何介导这些过程仍不清楚。在最近的一篇论文中，Progatzky 等人证明，EGC 在稳态和蠕虫感染下与免疫细胞和间皮细胞相互作用，揭示了干扰素-γ (IFNγ)-EGC-CXCL10 轴在组织修复中的不可或缺的作用。
Zotero 插件