Development and Homeostasis of the Nervous System Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Development and Homeostasis of the Nervous System Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Curr Opin Immunol. 2022 Aug;77:102183. doi: 10.1016/j.coi.2022.102183. Epub 2022 May 6.
The nervous system and immune system are important interfaces of the gastrointestinal tract that sense, integrate and respond to environmental stimuli and challenges. Enteric glial cells (EGCs), the non-neuronal cells of the enteric nervous system, were long considered mere bystanders only providing support for their workhorse neuronal neighbours. However, work by many groups has demonstrated that EGCs are important nodes in the intestinal tissue circuitry that regulate gastrointestinal barrier function, immunity, host defence and tissue repair. More recent studies have also begun to uncover the cellular interactions and molecular mechanisms that underpin the important functions of EGCs in intestinal physiology and pathophysiology. Here, we review recent literature investigating the roles of EGCs in intestinal immunity and tissue homeostasis.
神经系统和免疫系统是胃肠道的重要界面，它们可以感知、整合和响应环境刺激和挑战。肠胶质细胞（EGC）是肠神经系统的非神经元细胞，长期以来被认为只是为其主要神经元邻居提供支持的旁观者。然而，许多研究小组的工作表明，EGC 是调节胃肠道屏障功能、免疫、宿主防御和组织修复的肠道组织电路中的重要节点。最近的研究还开始揭示 EGC 在肠道生理学和病理生理学中发挥重要功能的细胞相互作用和分子机制。在这里，我们回顾了最近研究 EGC 在肠道免疫和组织稳态中的作用的文献。
