Xue Zhu, Li Juanli, Feng Jiaxing, Han Han, Zhao Jing, Zhang Jiao, Han Yanhua, Wu Xiaoke, Zhang Yuehui
The graduate school, Heilongjiang University of Chinese Medicine, Harbin, China.
The First Clinical Hospital Affiliated to Harbin Medical University, Harbin, China.
Front Physiol. 2021 Dec 17;12:788772. doi: 10.3389/fphys.2021.788772. eCollection 2021.
As a highly dynamic tissue, the endometrium is periodically shed in response to the secretion of estrogen and progesterone. After menarche, the endometrium of healthy women proliferates and differentiates under the action of steroid hormones (e.g., 17β-estradiol and progesterone) that are secreted by the ovaries to provide appropriate conditions for embryo implantation. Polycystic ovary syndrome (PCOS), a prevalent endocrine and metabolic disorder in reproductive-aged women, is usually associated with multiple cysts within the ovaries and excess levels of androgen and is characterized by hirsutism, acne, menstrual irregularity, infertility, and increased risk of insulin resistance. Multiple factors, such as anovulation, endocrine-metabolic abnormalities, and inflammation, can disrupt the endometrium in PCOS patients and can lead to endometrial hyperplasia, pregnancy complications, or even cancer. Despite many recent studies, the relationship between PCOS and abnormal endometrial function is still not fully understood. In this review, we investigate the correlation of PCOS patient endometrium with anovulation, hyperandrogenemia, insulin resistance, progesterone resistance, and inflammatory cytokines, aiming to provide a theoretical basis for the treatment of disorders caused by endometrial dysfunction in PCOS patients.
作为一种高度动态的组织，子宫内膜会根据雌激素和孕激素的分泌周期性脱落。初潮后，健康女性的子宫内膜在卵巢分泌的甾体激素（如17β-雌二醇和孕激素）作用下增殖和分化，为胚胎着床提供适宜条件。多囊卵巢综合征（PCOS）是育龄期女性中一种常见的内分泌和代谢紊乱疾病，通常与卵巢内多个囊肿以及雄激素水平过高有关，其特征为多毛、痤疮、月经不规律、不孕以及胰岛素抵抗风险增加。无排卵、内分泌代谢异常和炎症等多种因素会扰乱PCOS患者的子宫内膜，导致子宫内膜增生、妊娠并发症甚至癌症。尽管最近有许多研究，但PCOS与子宫内膜功能异常之间的关系仍未完全明确。在本综述中，我们研究PCOS患者子宫内膜与无排卵、高雄激素血症、胰岛素抵抗、孕激素抵抗及炎性细胞因子之间的相关性，旨在为治疗PCOS患者子宫内膜功能障碍所致疾病提供理论依据。
