Tang Haishuang, Zeng Zhangwei, Shang Chenghao, Li Qiang, Liu Jianmin
Department of Neurosurgery, Changhai Hospital, Naval Military Medical University, Shanghai, China.
Front Genet. 2021 Dec 15;12:810689. doi: 10.3389/fgene.2021.810689. eCollection 2021.
Atherosclerosis, characterized by atherosclerotic plaques, is a complex pathological process that involves different cell types and can be seen as a chronic inflammatory disease. In the advanced stage, the ruptured atherosclerotic plaque can induce deadly accidents including ischemic stroke and myocardial infarction. Epigenetics regulation, including DNA methylation, histone modification, and non-coding RNA modification. maintains cellular identity affecting the cellular transcriptome. The epigenetic modification process, mediating by epigenetic enzymes, is dynamic under various stimuli, which can be reversely altered. Recently, numerous studies have evidenced the close relationship between atherosclerosis and epigenetic regulations in atherosclerosis, providing us with a novel perspective in researching mechanisms and finding novel therapeutic targets of this serious disease. Here, we critically review the recent discoveries between epigenetic regulation mechanisms in atherosclerosis.
动脉粥样硬化以动脉粥样硬化斑块为特征，是一个复杂的病理过程，涉及不同细胞类型，可被视为一种慢性炎症性疾病。在晚期，破裂的动脉粥样硬化斑块可引发致命事故，包括缺血性中风和心肌梗死。表观遗传学调控，包括DNA甲基化、组蛋白修饰和非编码RNA修饰，维持细胞特性并影响细胞转录组。由表观遗传酶介导的表观遗传修饰过程在各种刺激下是动态的，可发生可逆改变。最近，大量研究证明了动脉粥样硬化与表观遗传学调控之间的密切关系，为我们研究这种严重疾病的发病机制和寻找新的治疗靶点提供了新的视角。在此，我们批判性地综述了动脉粥样硬化表观遗传调控机制的最新发现。
