Pande Purva, Suggu Sree Ramu, Bhalla Mala
All authors are with the Department of Dermatology, Venereology, and Leprosy at the Government Medical College and Hospital in Chandigarh, India.
J Clin Aesthet Dermatol. 2021 Jun;14(6 Suppl 1):S27-S29. Epub 2021 Jun 1.
Vitiligo affects one percent of general population and usually manifests in the second and third decades of life. Vitiligo is believed to be an acquired condition, though a positive family history is seen in 30 to 40 percent of cases. Few cases of vitiligo at birth have been reported. We report a case of congenital vitiligo in a neonate and discuss disease course and pathogenesis.
A 27- days-old female neonate patient presented with multiple, rapidly progressing, depigmented patches over the body that had been present since birth. The lesions showed chalky white accentuation under Wood's lamp. There was positive history of vitiligo in the mother. The child was started on topical fluticasone propionate 0.05% cream in the morning and tacrolimus 0.03% ointment at night. At the one-year of follow-up period, there were no new lesions, and partial repigmentation was noticed in the existing lesions.
Manifestation of vitiligo at birth is a very rare occurrence. The presentation at birth in this case suggests a genetic link, as opposed to acquired factors, and supports the in-utero hypothesis, adding to the scant literature available on congenital vitiligo.
白癜风影响着1%的普通人群，通常在人生的第二个和第三个十年出现。白癜风被认为是一种后天性疾病，尽管30%至40%的病例有阳性家族史。出生时患白癜风的病例报道很少。我们报告一例新生儿先天性白癜风病例，并讨论疾病过程和发病机制。
一名27日龄女婴自出生以来全身出现多处迅速进展的色素脱失斑。皮损在伍德灯下显示为白垩样白色。母亲有白癜风阳性病史。患儿晨起外用0.05%丙酸氟替卡松乳膏，夜间外用0.03%他克莫司软膏。随访一年时，无新皮损出现，现有皮损有部分色素再生。
出生时出现白癜风是非常罕见的情况。该病例出生时的表现提示与后天因素相反的遗传联系，并支持宫内假说，这为关于先天性白癜风的稀少文献增添了内容。
