Al-Bashaireh Ahmad M, Khraisat Omar, Alnazly Eman K, Aldiqs Mohannad
Faculty of Nursing, Al-Ahliyya Amman University, Amman, JOR.
Cureus. 2021 Nov 28;13(11):e19953. doi: 10.7759/cureus.19953. eCollection 2021 Nov.
Breast cancer is one of the most prevalent cancers in women. The improvement in breast cancer treatment has significantly increased the proportion of survival rate for women with breast cancer. Despite the advancement in breast cancer treatment, a great proportion of survivors suffer from co-occurring psychoneurological symptoms which impact their quality of life. The most frequently reported psychoneurological symptoms among women with breast cancer are depressive symptoms, anxiety, fatigue, sleep disturbances, and pain. These symptoms usually appear as a cluster. Inflammatory activation and serum metabolic alterations have been associated with the etiology of cancer and with various chronic neurocognitive disorders. However, to date, no studies considered the combined effects of inflammatory markers and metabolites in the development of psychoneurological symptoms in women with breast cancer especially those who were treated with chemotherapy. Further clarification of the relationships between the inflammatory markers, serum metabolic alterations, and psychoneurological symptoms in women with breast cancer should be pursued.
乳腺癌是女性中最常见的癌症之一。乳腺癌治疗的改善显著提高了乳腺癌女性的生存率。尽管乳腺癌治疗取得了进展，但很大一部分幸存者患有并发的精神神经症状，这影响了他们的生活质量。乳腺癌女性中最常报告的精神神经症状是抑郁症状、焦虑、疲劳、睡眠障碍和疼痛。这些症状通常以集群形式出现。炎症激活和血清代谢改变与癌症病因以及各种慢性神经认知障碍有关。然而，迄今为止，尚无研究考虑炎症标志物和代谢物在乳腺癌女性尤其是接受化疗的女性精神神经症状发生中的联合作用。应进一步阐明乳腺癌女性炎症标志物、血清代谢改变与精神神经症状之间的关系。
