Lanzhou University Second Hospital, Lanzhou University, Lanzhou, 730000, China.
Institute of National Nuclear Industry, Lanzhou University, Lanzhou, 730000, China.
Nanotheranostics. 2022 Jan 1;6(2):205-214. doi: 10.7150/ntno.67070. eCollection 2022.
Graphene quantum dots (GQD) have attracted much attention due to their unique properties in biomedical application, such as biosensing, imaging, and drug delivering. However, scale preparing red luminescing GQD is still challenging now. Herein, with the help of electron beam irradiation, a simple, rapid, and efficient up-to-down strategy was developed to synthesize GQD with size of 2.75 nm emitting 610 nm luminescence. GQD were further functionalized with polyethylene glycol (PEG) and exhibited good solubility and biocompatibility. The potential toxicity of PEGylated GQD could completely be eliminated by the clinic cholesterol-lowering drug simvastatin. PEGylated GQD could selectively accumulate in tumor after intravenous injection as a security, reliable and sensitive tumor fluorescence imaging agent. Therefore, this work presented a new method preparing red luminescing GQD for biomedical application.
石墨烯量子点（GQD）由于其在生物医学应用中的独特性质，如生物传感、成像和药物输送，引起了广泛关注。然而，目前规模制备红色发光 GQD 仍然具有挑战性。在此，借助电子束辐照，开发了一种简单、快速、高效的自上而下策略，用于合成尺寸为 2.75nm、发射 610nm 光的 GQD。GQD 进一步用聚乙二醇（PEG）功能化，表现出良好的溶解性和生物相容性。临床降胆固醇药物辛伐他汀可完全消除 PEG 化 GQD 的潜在毒性。PEG 化 GQD 经静脉注射后可选择性地在肿瘤中积累，作为一种安全、可靠和敏感的肿瘤荧光成像剂。因此，这项工作为生物医学应用提供了一种新的制备红色发光 GQD 的方法。
