Kuzin M I, Avrutskiĭ M Ia, Karelin A A, Babkina B M, Korotkina R N
Biull Eksp Biol Med. 1987 Aug;104(8):176-8.
The influence of diazepam, droperidol, fentanyl and central transcutaneous electrical stimulation (ES) on hepatocytes was studied in experiments on healthy rats (group I). Organospecific enzymes (histidase and urokinase) were chosen for the evaluation of side effects of drugs and their combination with ES on physiological functions of the liver. Drugs and their combinations with ES used in the clinical practice caused no marked damage of hepatocytes in healthy animals. A pronounced decrease in the above enzyme activity (3-fold, as compared to the control group) was revealed in rats with acute cholestasis and pancreatitis 72 h after ES. This fact shows hepatoprotective effects of ES. The most marked unfavourable effect on hepatocytes was registered in group II, where fentanyl was used.
在对健康大鼠进行的实验（第一组）中，研究了地西泮、氟哌利多、芬太尼和经皮中枢电刺激（ES）对肝细胞的影响。选择器官特异性酶（组氨酸酶和尿激酶）来评估药物及其与ES联合使用对肝脏生理功能的副作用。临床实践中使用的药物及其与ES的组合在健康动物中未引起肝细胞的明显损伤。在急性胆汁淤积和胰腺炎大鼠中，ES后72小时上述酶活性显著降低（与对照组相比降低了3倍）。这一事实表明ES具有肝保护作用。在使用芬太尼的第二组中，记录到对肝细胞最明显的不利影响。
