Kuzin M I, Karelin A A, Korotkina R N, Babkina N V, Shloznikov B M
Biull Eksp Biol Med. 1988 Sep;106(9):266-8.
Results obtained from the study of mechanisms of hepatoprotective effect of transcranial transcutaneous electrostimulation are cited (TTES). In experiments on cholestase and pancreatitis models in rats we studied hepatospecific enzymes i.e. histidase and urokininanse in blood and liver and membrane-linked enzyme 5'-nucleotidase in the liver tissue. We made three series of experiments: 1 - TTES + valium, 2 - synthetis hexapeptide (SH) - leuenkephaline analog; 3 - TTES + valium + SH. Results obtained from experiments showed that mechanisms of TTES hepatoprotective action are in part conditioned by endogenous opiopeptides mobilization which produced membranestabilizing effect on the hepatocyte. We concluded that in patients with hepatic pathology it was reasonable to combine the electroanesthesia with SH.
引用了经颅经皮电刺激（TTES）肝脏保护作用机制的研究结果。在大鼠胆汁淤积和胰腺炎模型实验中，我们研究了血液和肝脏中的肝脏特异性酶，即组氨酸酶和尿激酶，以及肝组织中的膜联酶5'-核苷酸酶。我们进行了三组实验：1 - TTES + 安定；2 - 合成六肽（SH）——亮脑啡肽类似物；3 - TTES + 安定 + SH。实验结果表明，TTES肝脏保护作用机制部分取决于内源性阿片肽的动员，其对肝细胞产生膜稳定作用。我们得出结论，对于肝脏疾病患者，将电麻醉与SH联合使用是合理的。
