Zhumadilov Zh Sh, Korotkina R N, Karelin A A
Vopr Med Khim. 1991 Mar-Apr;37(2):42-4.
Dynamics of glutathione-related enzymes activity was studied in erythrocytes of 22 dogs with destructive form of cholecystitis. As clinical symptoms of intoxication developed the enzymatic activity was decreased. In the animals with purulent-inflammatory complications distinct decrease was detected in activity of glutathione reductase (by 54.3%), glutathione-S-transferase--by 46.94% and glutathione peroxidase--by 42.1% (P less than 0.05). These data suggest that specific methods should be chosen for correction of impairments in the enzymatic activity in order to improve the treatment course efficiency as well as for prophylaxis of complications. The procedure developed for cholecystitis treatment, which involved channelled transport of antibiotics by means of autologous erythrocyte ghosts, proved to be more effective as compared with routine methods as shown by evaluation of the animals clinical state as well as by dynamics of hepato-specific enzymes activity and the glutathione-related enzymes activity. This procedure may be used in clinical practice; the laboratory tests described may serve for evaluation of the treatment course efficiency.
对22只患有坏疽性胆囊炎的犬的红细胞中谷胱甘肽相关酶活性的动态变化进行了研究。随着中毒临床症状的出现，酶活性降低。在患有化脓性炎症并发症的动物中，谷胱甘肽还原酶活性显著降低（降低54.3%），谷胱甘肽-S-转移酶活性降低46.94%，谷胱甘肽过氧化物酶活性降低42.1%（P<0.05）。这些数据表明，应选择特定方法来纠正酶活性损伤，以提高治疗过程的效率并预防并发症。通过自体红细胞空壳进行抗生素的定向转运所开发的胆囊炎治疗方法，与常规方法相比，在动物临床状态评估以及肝特异性酶活性和谷胱甘肽相关酶活性动态变化方面均显示出更有效。该方法可用于临床实践；所描述的实验室检测可用于评估治疗过程的效率。
