Cherniak V Ia, Koreshkov G G, Nasonov E L, Kogan-Iasnyĭ V V, Butylina I V
Biull Eksp Biol Med. 1987 Aug;104(8):226-9.
Circulating immune complexes (CIC) are of considerable importance in the pathogenesis of rheumatoid diseases. The study of CIC has so far been restricted to their stable forms. This paper presents the data of ultracentrifugation showing that sera from rheumatoid patients often contain special population of reversibly dissociating CIC. It is noted that antibodies forming such kinds of CIC might either be present in significant excess, as compared to antigens, or possess low affinity.
循环免疫复合物（CIC）在类风湿性疾病的发病机制中具有相当重要的意义。迄今为止，对CIC的研究仅限于其稳定形式。本文呈现了超速离心的数据，表明类风湿患者的血清中常含有可逆解离的CIC特殊群体。值得注意的是，形成这类CIC的抗体与抗原相比可能显著过量存在，或者具有低亲和力。
