Alberio Antonino Maria Quintilio, Pieroni Filippo, Di Gangi Alessandro, Cappelli Susanna, Bini Giulia, Abu-Rumeileh Sarah, Orsini Alessandro, Bonuccelli Alice, Peroni Diego, Assanta Nadia, Gaggiano Carla, Simonini Gabriele, Consolini Rita
Pediatrics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Rheumatology Unit, Meyer Children's Hospital, University of Florence, Florence, Italy.
Front Pediatr. 2021 Dec 15;9:746505. doi: 10.3389/fped.2021.746505. eCollection 2021.
To estimate the incidence of Acute Rheumatic Fever (ARF) in Tuscany, a region of Central Italy, evaluating the epidemiological impact of the new diagnostic guidelines, and to analyse our outcomes in the context of the Italian overview. A multicenter and retrospective study was conducted involving children <18 years old living in Tuscany and diagnosed in the period between 2010 and 2019. Two groups were established based on the new diagnostic criteria: High-Risk (HR) group patients, = 29 and Low-Risk group patients, = 96. ARF annual incidence ranged from 0.91 to 7.33 out of 100,000 children in the analyzed period, with peak of incidence registered in 2019. The application of HR criteria led to an increase of ARF diagnosis of 30%. Among the overall cohort joint involvement was the most represented criteria (68%), followed by carditis (58%). High prevalence of subclinical carditis was observed (59%). Tuscany should be considered an HR geographic area and HR criteria should be used for ARF diagnosis in this region.
为评估意大利中部托斯卡纳地区急性风湿热（ARF）的发病率，评估新诊断指南的流行病学影响，并在意大利总体情况的背景下分析我们的研究结果。我们开展了一项多中心回顾性研究，纳入了居住在托斯卡纳地区、2010年至2019年期间确诊的18岁以下儿童。根据新诊断标准设立了两组：高危（HR）组患者，n = 29；低危组患者，n = 96。在分析期间，ARF的年发病率为每10万名儿童中有0.91至7.33例，发病率峰值出现在2019年。应用HR标准使ARF诊断增加了30%。在整个队列中，关节受累是最主要的标准（68%），其次是心脏炎（58%）。观察到亚临床心脏炎的高患病率（59%）。托斯卡纳应被视为高危地理区域，该地区ARF诊断应采用HR标准。
