Zhang Qi, Wan Xin-Xing, Hu Xi-Min, Zhao Wen-Juan, Ban Xiao-Xia, Huang Yan-Xia, Yan Wei-Tao, Xiong Kun
Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, China.
Department of Endocrinology, Third Xiangya Hospital, Central South University, Changsha, China.
Front Cell Dev Biol. 2021 Dec 16;9:809656. doi: 10.3389/fcell.2021.809656. eCollection 2021.
Stem cell therapies have shown promising therapeutic effects in restoring damaged tissue and promoting functional repair in a wide range of human diseases. Generations of insulin-producing cells and pancreatic progenitors from stem cells are potential therapeutic methods for treating diabetes and diabetes-related diseases. However, accumulated evidence has demonstrated that multiple types of programmed cell death (PCD) existed in stem cells post-transplantation and compromise their therapeutic efficiency, including apoptosis, autophagy, necroptosis, pyroptosis, and ferroptosis. Understanding the molecular mechanisms in PCD during stem cell transplantation and targeting cell death signaling pathways are vital to successful stem cell therapies. In this review, we highlight the research advances in PCD mechanisms that guide the development of multiple strategies to prevent the loss of stem cells and discuss promising implications for improving stem cell therapy in diabetes and diabetes-related diseases.
干细胞疗法在修复受损组织和促进多种人类疾病的功能修复方面已显示出有前景的治疗效果。由干细胞生成胰岛素产生细胞和胰腺祖细胞是治疗糖尿病及糖尿病相关疾病的潜在治疗方法。然而，越来越多的证据表明，干细胞移植后存在多种类型的程序性细胞死亡（PCD），包括细胞凋亡、自噬、坏死性凋亡、细胞焦亡和铁死亡，这些会损害其治疗效果。了解干细胞移植过程中PCD的分子机制并靶向细胞死亡信号通路对于成功的干细胞治疗至关重要。在这篇综述中，我们重点介绍了PCD机制的研究进展，这些机制指导了多种防止干细胞丢失策略的发展，并讨论了在改善糖尿病及糖尿病相关疾病的干细胞治疗方面的有前景的意义。
