Yan Wei-Tao, Yang Yan-Di, Hu Xi-Min, Ning Wen-Ya, Liao Lyu-Shuang, Lu Shuang, Zhao Wen-Juan, Zhang Qi, Xiong Kun
Department of Neurobiology and Human Anatomy, School of Basic Medical Science, Central South University, Changsha, Hunan Province, China.
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Neural Regen Res. 2022 Aug;17(8):1761-1768. doi: 10.4103/1673-5374.331539.
Some scholars have recently developed the concept of PANoptosis in the study of infectious diseases where pyroptosis, apoptosis and necroptosis act in consort in a multimeric protein complex, PANoptosome. This allows all the components of PANoptosis to be regulated simultaneously. PANoptosis provides a new way to study the regulation of cell death, in that different types of cell death may be regulated at the same time. To test whether PANoptosis exists in diseases other than infectious diseases, we chose cerebral ischemia/reperfusion injury as the research model, collected articles researching cerebral ischemia/reperfusion from three major databases, obtained the original research data from these articles by bibliometrics, data mining and other methods, then integrated and analyzed these data. We selected papers that investigated at least two of the components of PANoptosis to check its occurrence in ischemia/reperfusion. In the cell model simulating ischemic brain injury, pyroptosis, apoptosis and necroptosis occur together and this phenomenon exists widely in different passage cell lines or primary neurons. Pyroptosis, apoptosis and necroptosis also occurred in rat and mouse models of ischemia/reperfusion injury. This confirms that PANoptosis is observed in ischemic brain injury and indicates that PANoptosis can be a target in the regulation of various central nervous system diseases.
最近，一些学者在传染病研究中提出了PAN细胞焦亡的概念，即细胞焦亡、凋亡和坏死性凋亡在一种多聚体蛋白复合物PAN小体中协同作用。这使得PAN细胞焦亡的所有组分能够同时受到调控。PAN细胞焦亡为研究细胞死亡的调控提供了一种新方法，因为不同类型的细胞死亡可能会同时受到调控。为了检验PAN细胞焦亡是否存在于传染病以外的其他疾病中，我们选择脑缺血/再灌注损伤作为研究模型，从三大数据库收集有关脑缺血/再灌注的研究文章，通过文献计量学、数据挖掘等方法从这些文章中获取原始研究数据，然后对这些数据进行整合和分析。我们挑选了至少研究了PAN细胞焦亡两个组分的论文，以检查其在缺血/再灌注中的发生情况。在模拟缺血性脑损伤的细胞模型中，细胞焦亡、凋亡和坏死性凋亡同时发生，并且这种现象广泛存在于不同传代的细胞系或原代神经元中。在缺血/再灌注损伤的大鼠和小鼠模型中也出现了细胞焦亡、凋亡和坏死性凋亡。这证实了在缺血性脑损伤中观察到了PAN细胞焦亡，表明PAN细胞焦亡可能是调控各种中枢神经系统疾病的一个靶点。
