Boehm T L, Ganser A, Heil G, Hoelzer D, Drahovsky D
Cancer Genet Cytogenet. 1987 Oct;28(2):327-34. doi: 10.1016/0165-4608(87)90219-6.
We describe a human acute unclassified leukemia with a unique t(4;17) translocation that coexpresses T-lymphoid and myeloid surface antigens after in vitro culture in the presence of the tumor promoter, TPA. Under these conditions, the joining regions of the immunoglobulin heavy chain and T-cell receptor gamma and beta chain complexes remained in germ line configuration. A T-cell receptor beta chain variable gene probe, however, revealed the presence of rearrangements in the V beta M3-2 gene region after bilineage differentiation. These results may be pertinent to the interrelationship of T-cell receptor gene rearrangements and the control of T-cell antigen surface expression.
我们描述了一种人类急性未分类白血病，其具有独特的t(4;17)易位，在肿瘤启动子佛波酯（TPA）存在的情况下进行体外培养后，共表达T淋巴细胞和髓系表面抗原。在这些条件下，免疫球蛋白重链以及T细胞受体γ和β链复合体的连接区域保持种系构型。然而，一个T细胞受体β链可变基因探针显示，在双系分化后VβM3-2基因区域存在重排。这些结果可能与T细胞受体基因重排和T细胞抗原表面表达的控制之间的相互关系有关。
