Pelicci P G, Knowles D M, Dalla Favera R
J Exp Med. 1985 Sep 1;162(3):1015-24. doi: 10.1084/jem.162.3.1015.
Ig and T beta gene rearrangements can be used as genetic markers of lineage and clonality in the study of B and T cell populations. We have addressed the issue of the respective B and T lineage specificity of these rearrangements by analyzing a panel of 63 lymphoid tumors representative of the various clinicopathologic categories of both B and T neoplasias. We report that approximately 10% of the cases tested displayed rearrangements of both Ig and T beta genes. Despite their dual genotypic pattern, these tumors retain a pure immunophenotype, i.e. they display either B or T cell lineage-restricted cell surface antigens. The implications of these findings for both normal and neoplastic lymphoid differentiation are discussed.
免疫球蛋白（Ig）和Tβ基因重排可作为B和T细胞群体研究中谱系和克隆性的遗传标记。我们通过分析一组63例代表B和T肿瘤各种临床病理类别的淋巴样肿瘤，探讨了这些重排各自的B和T谱系特异性问题。我们报告，约10%的检测病例显示Ig和Tβ基因均发生重排。尽管这些肿瘤具有双重基因型模式，但它们保留了纯免疫表型，即它们仅表达B或T细胞谱系限制性细胞表面抗原。本文讨论了这些发现对正常和肿瘤性淋巴样分化的意义。
