Nehama H, Wientroub S, Eisenberg Z, Birger A, Milbauer B, Weisman Y
Isr J Med Sci. 1987 Apr;23(4):274-7.
Seasonal changes were observed in the vitamin D status of mothers and their newly born infants in sunny Israel. Maternal and newborn serum levels of 25-hydroxyvitamin D (25-OHD) were lower (less than 0.01) in March-April (n = 45 pairs), than in September-October (n = 33 pairs). Parallel seasonal changes were also found in serum 24,25-dihydroxyvitamin D [24, 25-(OH)2D] concentrations. In the spring, 20% of the mothers and 40% of their infants had vitamin D deficiency or borderline serum 25-OHD levels. In the autumn, in contrast, none of the mothers and only one newborn were vitamin D-deficient, and one mother and two newborns had borderline serum 25-OHD levels. The results demonstrate that even in Mediterranean climates there are seasonal changes in maternal vitamin D status, which have a significant effect on the serum levels of vitamin D metabolites in their newborn infants. This raises the question as to whether vitamin D supplements should be given to pregnant women in Israel, at least during the winter.
在阳光充足的以色列，观察到母亲及其新生儿的维生素D状况存在季节性变化。3月至4月（n = 45对）母亲和新生儿的血清25-羟基维生素D（25-OHD）水平低于9月至10月（n = 33对）（小于0.01）。血清24,25-二羟基维生素D [24, 25-(OH)2D]浓度也发现了类似的季节性变化。春季，20%的母亲及其40%的婴儿存在维生素D缺乏或血清25-OHD水平处于临界值。相比之下，秋季没有母亲维生素D缺乏，只有一名新生儿维生素D缺乏，一名母亲和两名新生儿血清25-OHD水平处于临界值。结果表明，即使在地中海气候地区，母亲的维生素D状况也存在季节性变化，这对其新生儿的维生素D代谢物血清水平有显著影响。这就提出了一个问题，即以色列的孕妇是否应该补充维生素D，至少在冬季。
