维生素D、免疫系统与哮喘
Vitamin D, the immune system and asthma.
作者信息
Lange Nancy E, Litonjua Augusto, Hawrylowicz Catherine M, Weiss Scott
机构信息
Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham & Women's Hospital, 181 Longwood Avenue, Boston, MA 02115, USA Tel.: +1 617 525 0874
出版信息
Expert Rev Clin Immunol. 2009 Nov;5(6):693-702. doi: 10.1586/eci.09.53.
Abstract
The effects of vitamin D on bone metabolism and calcium homeostasis have long been recognized. Emerging evidence has implicated vitamin D as a critical regulator of immunity, playing a role in both the innate and cell-mediated immune systems. Vitamin D deficiency has been found to be associated with several immune-mediated diseases, susceptibility to infection and cancer. Recently, there has been increasing interest in the possible link between vitamin D and asthma. Further elucidation of the role of vitamin D in lung development and immune system function may hold profound implications for the prevention and treatment of asthma.
摘要
维生素D对骨代谢和钙稳态的影响早已为人所知。新出现的证据表明，维生素D是免疫的关键调节因子，在先天免疫系统和细胞介导的免疫系统中均发挥作用。已发现维生素D缺乏与多种免疫介导疾病、感染易感性和癌症有关。最近，人们对维生素D与哮喘之间可能存在的联系越来越感兴趣。进一步阐明维生素D在肺发育和免疫系统功能中的作用，可能对哮喘的预防和治疗具有深远意义。
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