Department of Hospital and Clinical Pharmacy, College of Pharmaceutical Sciences, Government Medical College, Vattappara, Kerala, India.
Division of Neurology, Department of Medicine, Queen's University, Kingston, Ontario, Canada.
Neurol India. 2021 Nov-Dec;69(6):1706-1710. doi: 10.4103/0028-3886.333437.
In patients with Parkinson's disease (PD), the occurrence of motor and non-motor symptoms increases with disease progression. The range of neuropsychiatric symptoms (NPS) vary among individuals and can be burdensome for caregivers. Only a few studies have identified the contributing factors of NPS and caregiver burden in India.
We aimed to study the clinical profile, disability, and predictive factors of NPS in PD patients and associated caregiver's burden.
This was a cross-sectional observational study carried out in PD patients and their respective caregivers attending a movement disorder clinic in a tertiary care teaching hospital in Kerala. A total of 104 patients diagnosed with idiopathic PD receiving levodopa therapy and who had a primary caregiver were enrolled in the study. Structured questionnaires were administered to both patients and caregivers to collect data. Data analysis was done using an independent t-test, linear, and multiple regression analysis.
Among 104 patients recruited for the study, 61.5% of patients had shown at least one NPS and 40.44% showed multiple NPS. Results from the study showed that depression is the primary NPS occurring in IPD patients (55.8%) followed by irritability, anxiety, and apathy. On linear regression models, the prime determinant of NPS was the Everyday Abilities Scale for India (EASI). For caregiver burden, the main determinants were the presence of NPS, duration of caregiving, EASI, and RBDSQ score.
NPS in PD are highly associated with and are determinants of caregiver burden. Detailed assessment and specific interventions aimed at NPS could alleviate caregiver burden.
在帕金森病（PD）患者中，运动和非运动症状随着疾病的进展而增加。神经精神症状（NPS）的范围因人而异，可能会给照顾者带来负担。只有少数研究在印度确定了 NPS 和照顾者负担的促成因素。
我们旨在研究 PD 患者的 NPS 临床特征、残疾和预测因素，以及相关的照顾者负担。
这是一项在喀拉拉邦一家三级护理教学医院的运动障碍诊所就诊的 PD 患者及其各自照顾者中进行的横断面观察性研究。共有 104 名被诊断为接受左旋多巴治疗的特发性 PD 患者和一名主要照顾者入组了这项研究。对患者和照顾者进行了结构问卷调查以收集数据。使用独立 t 检验、线性和多元回归分析进行数据分析。
在纳入研究的 104 名患者中，61.5%的患者至少出现了一种 NPS，40.44%的患者出现了多种 NPS。研究结果表明，抑郁是 IPD 患者中主要的 NPS（55.8%），其次是易怒、焦虑和淡漠。在线性回归模型中，NPS 的主要决定因素是印度日常能力量表（EASI）。对于照顾者负担，主要决定因素是 NPS 的存在、照顾时间、EASI 和 RBDSQ 评分。
PD 中的 NPS 与照顾者负担高度相关，也是其决定因素。对 NPS 的详细评估和特定干预措施可能会减轻照顾者的负担。
