Ophthalmic Plastic Surgery Service, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, India.
Image Reading Center, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, India.
Orbit. 2022 Feb;41(1):89-96. doi: 10.1080/01676830.2021.2014893. Epub 2022 Jan 4.
To report the differences in choroidal vascularity index (CVI) in thyroid eye disease (TED) and normals and its discriminatory value for differentiating various stages of TED.
Prospective, cross-sectional, non-interventional imaging study. Ninety-four eyes of 54 patients were included and divided into 5 groups - normal controls (C), inactive TED (I), active TED (A), non-inflammatory active TED (NIA) and systemic hyperthyroid disorder but no TED (SYS). Choroidal images were acquired using the swept-source optical coherence tomography and the choroid was binarized to calculate the CVI.
Ninety-four eyes were included. Mean age was 44.52 ± 10.02 years (median 46 years, range 19-65 years). Mean IOP was 16.1 ± 3.37 mm Hg (median 16 mm Hg, range 16-24 mm Hg). Mean Spherical equivalent (SE) was -0.08 ± 1.86 diopters (median 0, range -2.5 to +2.25). Intra-rater agreement was 0.84 ( < 0.001). Inter-rater agreement was noted to be 0.85 ( < 0.001) for consistency and 0.77 ( < 0.001) for absolute agreement. CVI in the A group was 70.11 ± 3.38% and in the NIA group was 69.32 ± 3.5%. Both were comparable to each other and significantly higher than the C, I and SYS groups ( < 0.001). Multiple regression showed that the Clinical Activity Score (CAS) had a positive effect and spheroequivalent had a negative effect on the CVI. At CVI of 66.83%, active TED can be diagnosed with sensitivity of 91.67% and specificity of 82.14% .
CVI is significantly higher in active TED and NIA TED compared to other groups. It has a good value in differentiating the non-inflammatory active TED eyes from the inactive eyes.
报告甲状腺眼病（TED）和正常人群脉络膜血管指数（CVI）的差异及其鉴别 TED 各期的价值。
前瞻性、横断面、非干预性影像学研究。纳入 54 例患者的 94 只眼，分为 5 组：正常对照组（C）、非活动期 TED（I）、活动期 TED（A）、非炎症性活动期 TED（NIA）和全身甲状腺功能亢进但无 TED（SYS）。使用扫频源光学相干断层扫描获取脉络膜图像，并对脉络膜进行二值化处理以计算 CVI。
纳入 94 只眼。平均年龄为 44.52±10.02 岁（中位数 46 岁，范围 19-65 岁）。平均眼压为 16.1±3.37mmHg（中位数 16mmHg，范围 16-24mmHg）。平均等效球镜（SE）为-0.08±1.86 屈光度（中位数 0，范围-2.5 至+2.25）。内部观察者间的一致性为 0.84（<0.001）。观察者间的一致性为 0.85（<0.001）的一致性和 0.77（<0.001）的绝对一致性。A 组的 CVI 为 70.11±3.38%，NIA 组为 69.32±3.5%。两者相互比较均显著高于 C、I 和 SYS 组（<0.001）。多元回归显示，临床活动评分（CAS）呈正效应，等效球镜呈负效应。当 CVI 为 66.83%时，可诊断为活动期 TED，其敏感性为 91.67%，特异性为 82.14%。
与其他组相比，活动期 TED 和非炎症性活动期 TED 的 CVI 显著升高。它在鉴别非炎症性活动期 TED 眼与非活动期眼方面具有良好的价值。
