Conte D, Ferroni P, Lorini G P, Aimo G P, Mandelli C, Cesana M, Brunelli L, Bignotti G C, Bianchi P A, Zanetti A R
J Med Virol. 1987 Aug;22(4):299-306. doi: 10.1002/jmv.1890220402.
Three hundred and two intravenous drug addicts (IVDA) from five towns in Northeastern Italy were studied. Of the males, 37/249 (14.8%) were homosexuals and of the females, 29/53 (54.7%) were prostitutes; 118 (39.0%) were alcoholics. AST levels were abnormal in 31.8%, ALT in 45.7%, GTP in 36.4%, and bilirubin in 14.6%. The prevalence of HBsAg (13.9%) and HBeAg (21.4% of HBsAg positive) was significantly higher than in 2,983 controls (4.2% and 6.3%, p less than .001 and p less than .02, respectively). Of the HBsAg positive subjects, 51.7% had anti-HDV antibodies. Among 260 HBsAg negative cases, 146 (56.2%) were anti-HBs and anti-HBc positive, 76 (29.2%) were anti-HBc positive and anti-HBs negative (25 anti-HBe positive and 51 anti-HBe negative), and 38 had no HBV markers. Anti-HIV ELISA positive subjects came to 70.5% (triplicate determination with absolute concordance) and Western blot analysis confirmed the results in 99.1% of ELISA positive and 100% of ELISA negative subjects. The prevalence of anti-HIV was significantly higher in anti-HBc positive than negative cases (p less than .02), even excluding HBsAg positive subjects. Cases negative for HIV and HBV had a significantly lower median duration of drug abuse than those with past or present infection (36 vs 60 months, p less than .001). HIV-related diseases were present in 56.3% of the cases (120/213; PGL in 94, ARC in 24, and AIDS in two).(ABSTRACT TRUNCATED AT 250 WORDS)
对来自意大利东北部五个城镇的302名静脉注射吸毒者（IVDA）进行了研究。男性中，37/249（14.8%）为同性恋者，女性中，29/53（54.7%）为妓女；118人（39.0%）酗酒。天门冬氨酸氨基转移酶（AST）水平异常者占31.8%，丙氨酸氨基转移酶（ALT）异常者占45.7%，γ-谷氨酰转肽酶（GTP）异常者占36.4%，胆红素异常者占14.6%。乙肝表面抗原（HBsAg）的流行率（13.9%）和乙肝e抗原（HBeAg，在HBsAg阳性者中占21.4%）显著高于2983名对照者（分别为4.2%和6.3%，p<0.001和p<0.02）。在HBsAg阳性者中，51.7%有抗丁型肝炎病毒（HDV）抗体。在260例HBsAg阴性病例中，146例（56.2%）抗-HBs和抗-HBc阳性，76例（29.2%）抗-HBc阳性而抗-HBs阴性（25例抗-HBe阳性，51例抗-HBe阴性），38例无乙肝病毒标志物。抗-HIV酶联免疫吸附测定（ELISA）阳性者达70.5%（三次重复测定结果完全一致），免疫印迹分析在99.1%的ELISA阳性者和100%的ELISA阴性者中证实了结果。即使排除HBsAg阳性者，抗-HBc阳性病例中抗-HIV的流行率也显著高于阴性病例（p<0.02）。HIV和HBV均阴性的病例滥用药物的中位持续时间显著低于有既往或现感染的病例（36个月对60个月，p<0.001）。56.3%的病例（120/213）患有与HIV相关的疾病（94例有卡波西肉瘤，24例患艾滋病相关综合征，2例患艾滋病）。（摘要截短于250字）
