Kaye E M, Butler I J, Conley S
J Neurol Neurosurg Psychiatry. 1987 Jul;50(7):923-6. doi: 10.1136/jnnp.50.7.923.
Two children with lupus erythematosus and myelopathy were studied. The first child developed the neonatal lupus erythematosus syndrome associated with transplacentally acquired anti-Ro/SSA antibodies. The cutaneous manifestations of neonatal lupus erythematosus disappeared but a residual myelopathy was confirmed at 16 months of age. The second child developed cutaneous lupus erythematosus at 3 months of age associated with a total deficiency of the Clr component of complement. A myelopathy and mesangial glomerulonephritis developed at 2 years of age which required treatment with corticosteroids. These two children with CNS lupus erythematosus, one associated with transplacentally acquired antibodies and the other associated with a complement deficiency, may suggest an immune-mediated mechanism for the pathogenesis of myelopathy in childhood lupus erythematosus.
对两名患有红斑狼疮和脊髓病的儿童进行了研究。第一个儿童患有与经胎盘获得的抗Ro/SSA抗体相关的新生儿红斑狼疮综合征。新生儿红斑狼疮的皮肤表现消失，但在16个月大时确诊存在残留脊髓病。第二个儿童在3个月大时出现皮肤红斑狼疮，与补体Clr成分完全缺乏有关。2岁时出现脊髓病和系膜增生性肾小球肾炎，需要用皮质类固醇进行治疗。这两名患有中枢神经系统红斑狼疮的儿童，一名与经胎盘获得的抗体有关，另一名与补体缺乏有关，可能提示儿童红斑狼疮脊髓病发病机制中的免疫介导机制。
