低负荷抗阻训练联合不同程度血流限制对膝骨关节炎患者的影响：一项随机试验的研究方案。
Effect of low-load resistance training with different degrees of blood flow restriction in patients with knee osteoarthritis: study protocol for a randomized trial.
机构信息
School of Sport Medicine and Rehabilitation, Beijing Sport University, No. 48 Xinxi Road, Haidian District, Beijing, 100084, China.
出版信息
Trials. 2022 Jan 3;23(1):6. doi: 10.1186/s13063-021-05946-7.
BACKGROUND
Knee osteoarthritis (KOA) is a common degenerative disease that causes pain, functional impairment, and reduced quality of life. Resistance training is considered as an effective approach to reduce the risk of muscle weakness in patients with KOA. Blood flow restriction (BFR) with low-load resistance training has better clinical outcomes than low-load resistance training alone. However, the degree of BFR which works more effectively with low-load resistance training has not been determined. The purpose of this study is to evaluate the effectiveness of different degrees of BFR with low-load resistance training in patients with KOA on pain, self-reported function, physical function performance, muscle strength, muscle thickness, and quality of life.
METHODS
This is a study protocol for a randomized, controlled trial with blinded participants. One hundred individuals will be indiscriminately assigned into the following groups: two training groups with a BFR at 40% and 80% limb occlusion pressure (LOP), a training group without BFR, and a health education group. The three intervention groups will perform strength training for the quadriceps muscles twice a week for 12 weeks, while the health education group will attend sessions once a week for 12 weeks. The primary outcome is pain. The secondary outcomes include self-reported function, physical function performance, muscle strength of the knee extensors, muscle mass of the quadriceps, quality of life, and adverse events. Intention-to-treat analysis will be conducted for individuals who withdraw during the trial.
DISCUSSION
Previous studies have shown that BFR with low-load resistance training is more effective than low-load resistance training alone; however, a high degree of BFR may cause discomfort during training. If a 40% LOP for BFR could produce similar clinical outcomes as an 80% LOP for BFR, resistance training with a low degree of BFR can be chosen for patients with KOA who are unbearable for a high degree of BFR.
TRIAL REGISTRATION
Chinese Clinical Trial Registry ChiCTR2000037859 ( http://www.chictr.org.cn/edit.aspx?pid=59956&htm=4 ). Registered on 2 September 2020.
背景
膝骨关节炎（KOA）是一种常见的退行性疾病，可导致疼痛、功能障碍和生活质量下降。阻力训练被认为是降低 KOA 患者肌肉无力风险的有效方法。与单独进行低负荷阻力训练相比，血流限制（BFR）结合低负荷阻力训练具有更好的临床效果。然而，BFR 与低负荷阻力训练相结合的更有效程度尚未确定。本研究旨在评估 BFR 结合低负荷阻力训练对 KOA 患者疼痛、自我报告功能、身体功能表现、肌肉力量、肌肉厚度和生活质量的影响。
方法
这是一项随机、对照试验的研究方案，参与者为双盲。将 100 名个体随机分为以下组：BFR 组（40%和 80%肢体闭塞压力[LOP]）、无 BFR 组和健康教育组。三组干预组每周进行两次股四头肌力量训练，共 12 周，健康教育组每周参加一次，共 12 周。主要结局是疼痛。次要结局包括自我报告功能、身体功能表现、膝关节伸肌力量、股四头肌肌肉质量、生活质量和不良事件。对试验期间退出的个体进行意向治疗分析。
讨论
先前的研究表明，BFR 结合低负荷阻力训练比单独进行低负荷阻力训练更有效；然而，高程度的 BFR 在训练过程中可能会引起不适。如果 BFR 采用 40%的 LOP 可以产生与 BFR 采用 80%的 LOP 相似的临床效果，那么对于难以承受高程度 BFR 的 KOA 患者，可以选择低程度 BFR 的阻力训练。
试验注册
中国临床试验注册中心 ChiCTR2000037859（http://www.chictr.org.cn/edit.aspx?pid=59956&htm=4）。注册于 2020 年 9 月 2 日。
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