多形核白细胞上补体受体功能的定量：其在系统性红斑狼疮患者中的意义。
Quantification of the complement receptor function on polymorphonuclear leukocytes: its significance in patients with systemic lupus erythematosus.
作者信息
Yoshida K, Yukiyama Y, Miyamoto T
出版信息
J Rheumatol. 1987 Jun;14(3):490-6.
PMID:3498035
Abstract
The function of complement receptors (CR1) on polymorphonuclear leukocytes (PMN) was assessed by C3b mediated binding of immune complexes (IC) to PMN. The binding of IC to CR1 on PMN depends on the activation of the classical complement pathway and was inhibited by the antibody to CR1 or C3b. CR1 function of PMN from patients with systemic lupus erythematosus was reduced compared with those from normal controls or patients with rheumatoid arthritis.
摘要
通过C3b介导免疫复合物（IC）与多形核白细胞（PMN）的结合来评估PMN上补体受体（CR1）的功能。IC与PMN上CR1的结合取决于经典补体途径的激活，并受到抗CR1或C3b抗体的抑制。与正常对照或类风湿性关节炎患者相比，系统性红斑狼疮患者的PMN的CR1功能降低。
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