• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Impact of Berberine on Some Epigenetic, Transcription Regulation and Inflammatory Biomarkers in a Mice Model of Epilepsy.小檗碱对癫痫小鼠模型中某些表观遗传、转录调控及炎症生物标志物的影响
Rep Biochem Mol Biol. 2021 Oct;10(3):362-372. doi: 10.52547/rbmb.10.3.362.
2
Berberine ameliorates intrahippocampal kainate-induced status epilepticus and consequent epileptogenic process in the rat: Underlying mechanisms.小檗碱改善大鼠海马内红藻氨酸诱导的癫痫持续状态及随后的致痫过程：潜在机制
Biomed Pharmacother. 2017 Mar;87:200-208. doi: 10.1016/j.biopha.2016.12.109. Epub 2017 Jan 3.
3
Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models.缺氧诱导因子-1α表达的改变参与动物模型的癫痫发生过程。
Synapse. 2014 Sep;68(9):402-9. doi: 10.1002/syn.21752. Epub 2014 Jun 17.
4
Berberine improves insulin-induced diabetic retinopathy through exclusively suppressing Akt/mTOR-mediated HIF-1α/VEGF activation in retina endothelial cells.小檗碱通过特异性抑制 Akt/mTOR 介导的视网膜内皮细胞中 HIF-1α/VEGF 的激活来改善胰岛素诱导的糖尿病视网膜病变。
Int J Biol Sci. 2021 Oct 20;17(15):4316-4326. doi: 10.7150/ijbs.62868. eCollection 2021.
5
Inhibiting HIF-1α Decreases Expression of TNF-α and Caspase-3 in Specific Brain Regions Exposed Kainic Acid-Induced Status Epilepticus.抑制缺氧诱导因子-1α可降低在暴露于 kainic 酸诱导的癫痫持续状态的特定脑区中肿瘤坏死因子-α和半胱天冬酶-3 的表达。
Cell Physiol Biochem. 2016;38(1):75-82. doi: 10.1159/000438610. Epub 2016 Jan 8.
6
Berberine inhibits HIF-1alpha expression via enhanced proteolysis.小檗碱通过增强蛋白水解作用抑制缺氧诱导因子-1α（HIF-1α）的表达。
Mol Pharmacol. 2004 Sep;66(3):612-9.
7
Berberine radiosensitizes human nasopharyngeal carcinoma by suppressing hypoxia-inducible factor-1α expression.黄连素通过抑制缺氧诱导因子-1α的表达使人类鼻咽癌对放疗增敏。
Acta Otolaryngol. 2014 Feb;134(2):185-92. doi: 10.3109/00016489.2013.850176. Epub 2013 Dec 10.
8
Plant Isoquinoline Alkaloid Berberine Exhibits Chromatin Remodeling by Modulation of Histone Deacetylase To Induce Growth Arrest and Apoptosis in the A549 Cell Line.植物异喹啉生物碱黄连素通过调节组蛋白脱乙酰酶表现出染色质重塑，从而诱导A549细胞系生长停滞和凋亡。
J Agric Food Chem. 2016 Dec 21;64(50):9542-9550. doi: 10.1021/acs.jafc.6b04453. Epub 2016 Dec 12.
9
Epigenetic regulation in epilepsy: A novel mechanism and therapeutic strategy for epilepsy.癫痫的表观遗传调控：癫痫的一种新机制和治疗策略。
Neurochem Int. 2024 Feb;173:105657. doi: 10.1016/j.neuint.2023.105657. Epub 2023 Dec 23.
10
Hypoxia-inducible factor 1 mediates the anti-apoptosis of berberine in neurons during hypoxia/ischemia.缺氧诱导因子1介导黄连素在缺氧/缺血时对神经元的抗凋亡作用。
Acta Physiol Hung. 2012 Sep;99(3):311-23. doi: 10.1556/APhysiol.99.2012.3.8.

引用本文的文献

1
Natural anti-cancer products: insights from herbal medicine.天然抗癌产品：来自草药医学的见解。
Chin Med. 2025 Jun 9;20(1):82. doi: 10.1186/s13020-025-01124-y.
2
Neuroprotective effect and preparation methods of berberine.黄连素的神经保护作用及制备方法。
Front Pharmacol. 2024 Sep 6;15:1429050. doi: 10.3389/fphar.2024.1429050. eCollection 2024.
3
Inhibition of Neuron-Restrictive Silencing Factor (REST/NRSF) Chromatin Binding Attenuates Epileptogenesis.抑制神经元限制沉默因子（REST/NRSF）染色质结合可减轻癫痫发生。
eNeuro. 2024 May 17;11(5). doi: 10.1523/ENEURO.0006-24.2024. Print 2024 May.
4
Anti-seizure Effects and Mechanisms of Berberine: A Systematic Review.小檗碱的抗惊厥作用及其机制：系统评价。
Curr Pharm Biotechnol. 2024;25(17):2253-2265. doi: 10.2174/0113892010283237240107121749.
5
Suppression of colon cancer growth by berberine mediated by the intestinal microbiota and the suppression of DNA methyltransferases (DNMTs).肠道微生物群和 DNA 甲基转移酶（DNMTs）介导的小檗碱抑制结肠癌生长。
Mol Cell Biochem. 2024 Aug;479(8):2131-2141. doi: 10.1007/s11010-023-04836-7. Epub 2023 Aug 28.
6
Recent studies on berberine and its biological and pharmacological activities.小檗碱及其生物学和药理学活性的最新研究。
EXCLI J. 2023 Feb 28;22:315-328. doi: 10.17179/excli2022-5898. eCollection 2023.

本文引用的文献

1
The Influence of Palmatine Isolated from on Pentylenetetrazole-Induced Seizures in Zebrafish.从黄连中分离得到的小檗碱对戊四氮诱导斑马鱼癫痫发作的影响。
Cells. 2020 May 16;9(5):1233. doi: 10.3390/cells9051233.
2
Epigenome-wide association study of seizures in childhood and adolescence.儿童和青少年癫痫的全基因组关联研究。
Clin Epigenetics. 2020 Jan 8;12(1):8. doi: 10.1186/s13148-019-0793-z.
3
Syntaxin 1B Mediates Berberine's Roles in Epilepsy-Like Behavior in a Pentylenetetrazole-Induced Seizure Zebrafish Model.Syntaxin 1B介导小檗碱在戊四氮诱导癫痫发作斑马鱼模型中类癫痫行为中的作用。
Front Mol Neurosci. 2018 Nov 26;11:378. doi: 10.3389/fnmol.2018.00378. eCollection 2018.
4
Serum Levels of Brain-Derived Neurotrophic Factor and Insulin-Like Growth Factor 1 Are Associated With Autonomic Dysfunction and Impaired Cerebral Autoregulation in Patients With Epilepsy.癫痫患者血清脑源性神经营养因子和胰岛素样生长因子1水平与自主神经功能障碍及脑自动调节受损相关。
Front Neurol. 2018 Nov 20;9:969. doi: 10.3389/fneur.2018.00969. eCollection 2018.
5
Berberine decelerates glucose metabolism via suppression of mTOR‑dependent HIF‑1α protein synthesis in colon cancer cells.小檗碱通过抑制 mTOR 依赖性 HIF-1α 蛋白合成来减缓结肠癌细胞中的葡萄糖代谢。
Oncol Rep. 2018 May;39(5):2436-2442. doi: 10.3892/or.2018.6318. Epub 2018 Mar 16.
6
MiR-153 regulates expression of hypoxia-inducible factor-1α in refractory epilepsy.微小RNA-153调节难治性癫痫中缺氧诱导因子-1α的表达。
Oncotarget. 2018 Jan 5;9(9):8542-8547. doi: 10.18632/oncotarget.24012. eCollection 2018 Feb 2.
7
Enduring Memory Impairments Provoked by Developmental Febrile Seizures Are Mediated by Functional and Structural Effects of Neuronal Restrictive Silencing Factor.发育性热性惊厥引发的持久性记忆障碍由神经元限制性沉默因子的功能和结构效应介导。
J Neurosci. 2017 Apr 5;37(14):3799-3812. doi: 10.1523/JNEUROSCI.3748-16.2017. Epub 2017 Mar 8.
8
Pilocarpine-Induced Status Epilepticus Is Associated with Changes in the Actin-Modulating Protein Synaptopodin and Alterations in Long-Term Potentiation in the Mouse Hippocampus.毛果芸香碱诱导的癫痫持续状态与小鼠海马中肌动蛋白调节蛋白突触足蛋白的变化及长时程增强的改变有关。
Neural Plast. 2017;2017:2652560. doi: 10.1155/2017/2652560. Epub 2017 Jan 5.
9
NRSF-dependent epigenetic mechanisms contribute to programming of stress-sensitive neurons by neonatal experience, promoting resilience.NRSF 依赖性表观遗传机制有助于通过新生体验编程应激敏感神经元，促进恢复力。
Mol Psychiatry. 2018 Mar;23(3):648-657. doi: 10.1038/mp.2016.240. Epub 2017 Jan 10.
10
Berberine ameliorates intrahippocampal kainate-induced status epilepticus and consequent epileptogenic process in the rat: Underlying mechanisms.小檗碱改善大鼠海马内红藻氨酸诱导的癫痫持续状态及随后的致痫过程：潜在机制
Biomed Pharmacother. 2017 Mar;87:200-208. doi: 10.1016/j.biopha.2016.12.109. Epub 2017 Jan 3.

小檗碱对癫痫小鼠模型中某些表观遗传、转录调控及炎症生物标志物的影响

Impact of Berberine on Some Epigenetic, Transcription Regulation and Inflammatory Biomarkers in a Mice Model of Epilepsy.

作者信息

Ghanem Heba Bassiony, Emam Marwa Nagy, Dareen Abdelaziz Mohammed Ali, Rania Nagi Abd-Ellatif

机构信息

Clinical laboratory sciences Department, College of Applied Medical Sciences, Jouf University, Sakaka, Saudi Arabia.

Medical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

出版信息

Rep Biochem Mol Biol. 2021 Oct;10(3):362-372. doi: 10.52547/rbmb.10.3.362.

DOI:10.52547/rbmb.10.3.362
PMID:34981012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8718772/
Abstract

BACKGROUND

Epilepsy is one of the most widespread neurological disease worldwide. Status epilepticus (SE) is a life-threatening neurologic disorder. Neuroprotective approaches are increasingly to discover a promising therapy to manage epileptic disorders. This study aimed to assess the impact of berberine on some epigenetic, transcription regulation & inflammatory biomarkers in a mice model of epilepsy.

METHODS

This work was performed on; Group I: (control), Group II: berberine-treated control,Group III: epilepsy group, Group IV: berberine-treated epilepsy. Groups were subjected to assessment of Tumor growth factor-1β (TGF-1β), hypoxia inducible factor-1α (HIF-1α), brain derived neurotrophic factor (BDNF) levels, histone deacetylase (HDAC) activity & neuronal restrictive silencing factor (NRSF) gene expression.

RESULTS

Study showed significant increase in levels of HIF-1α, TGF-1β, HDAC activity & NRSF gene expression in epilepsy group & decrease in these levels in berberine treated epilepsy group. Significant decrease in BDNF levels in epilepsy & elevation in them in berberine treated epilepsy group.

CONCLUSION

Our study showed the anti-epileptic impact of berberine via its regulatory effect on some epigenetic, transcription factors & inflammatory biomarkers in a mice model of epilepsy.

摘要

背景

癫痫是全球最普遍的神经系统疾病之一。癫痫持续状态（SE）是一种危及生命的神经系统疾病。神经保护方法越来越多地用于寻找治疗癫痫疾病的有效疗法。本研究旨在评估黄连素对癫痫小鼠模型中一些表观遗传、转录调控和炎症生物标志物的影响。

方法

本研究分为四组进行：第一组（对照组）、第二组（黄连素处理的对照组）、第三组（癫痫组）、第四组（黄连素处理的癫痫组）。对各组进行肿瘤生长因子-1β（TGF-1β）、缺氧诱导因子-1α（HIF-1α）、脑源性神经营养因子（BDNF）水平、组蛋白脱乙酰酶（HDAC）活性及神经元限制性沉默因子（NRSF）基因表达的评估。

结果

研究表明，癫痫组中HIF-1α、TGF-1β、HDAC活性及NRSF基因表达水平显著升高，而黄连素处理的癫痫组这些水平降低。癫痫组中BDNF水平显著降低，而黄连素处理的癫痫组中BDNF水平升高。

结论

我们的研究表明，黄连素在癫痫小鼠模型中通过对一些表观遗传、转录因子和炎症生物标志物的调节作用具有抗癫痫作用。