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基于英格兰、威尔士、北爱尔兰和马恩岛国家联合登记处以及英格兰国家 PROM 收集计划,对骨水泥固定型和非骨水泥固定型全膝关节置换术患者报告的结局测量指标进行配对比较。

A matched comparison of the patient-reported outcome measures of cemented and cementless total knee replacements, based on the National Joint Registry of England, Wales, Northern Ireland, and Isle of Man and England's National PROM collection programme.

机构信息

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences University of Oxford, Nuffield Orthopaedic Centre, Oxford.

Musculoskeletal Research Unit, Bristol Medical School, University of Bristol, UK.

出版信息

Acta Orthop. 2022 Jan 3;93:164-170. doi: 10.2340/17453674.2021.896.

DOI:10.2340/17453674.2021.896
PMID:34981127
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8815428/
Abstract

Background and purpose - Total knee replacement (TKR) can be implanted with or without bone cement. It is currently unknown how the functional outcomes compare. Therefore, we compared the patient-reported outcome measures (PROMS) of both fixation methods. Patients and methods - We performed a propensitymatched comparison of 14,404 TKRs (7,202 cemented and 7,202 cementless) enrolled in the National Joint Registry and the English National PROMs collection programme. Subgroup analyses were performed in different age groups (1) < 55 years; (2) 55-64 years; (3) 65-74 years; (4) ≥ 75 years. Results - The 6-month postoperative Oxford Knee Score (OKS) was significantly (p < 0.001) higher for cemented TKR (35, SD 9.7) than cementless TKR (34, SD 9.9). The OKS was also significantly higher for the cemented TKR in all age groups, except the 55-64-year group. A significantly higher proportion of cemented TKRs had an excellent OKS (≥ 41) compared with cementless (32% vs. 28%, p < 0.001) and a lower proportion of poor (< 27) scores (19% vs. 22%, p = 0.001). This was also observed for all age subgroups. There were no significant differences in EQ-5D points gained postoperatively between the groups respectively (0.31 vs. 0.30, p = 0.1). Interpretation - Cemented TKRs had a greater proportion of excellent OKS scores and lower proportion of poor scores both overall and across all age groups. However, the absolute differences are small and below the minimally clinically important difference, making both fixation types acceptable. Currently the vast majority of TKRs are cemented and the results from this study suggest that this is appropriate.

摘要

背景与目的-全膝关节置换术(TKR)可采用或不采用骨水泥进行植入。目前尚不清楚这两种固定方法的功能结果如何比较。因此,我们比较了两种固定方法的患者报告的结果测量指标(PROMs)。

患者和方法-我们对全国关节登记处和英国国家 PROMs 收集计划中纳入的 14404 例 TKR(7202 例骨水泥固定和 7202 例非骨水泥固定)进行了倾向评分匹配比较。在不同年龄组(1)<55 岁;(2)55-64 岁;(3)65-74 岁;(4)≥75 岁进行了亚组分析。

结果-术后 6 个月时,骨水泥固定 TKR 的牛津膝关节评分(OKS)(35,SD9.7)显著(p<0.001)高于非骨水泥固定 TKR(34,SD9.9)。除 55-64 岁组外,骨水泥固定 TKR 在所有年龄组的 OKS 也显著更高。与非骨水泥固定 TKR 相比,骨水泥固定 TKR 有更高比例的患者具有极好的 OKS(≥41)(32%比 28%,p<0.001)和更低比例的较差评分(<27)(19%比 22%,p=0.001)。所有年龄亚组也观察到了这一点。两组术后 EQ-5D 评分分别增加(0.31 比 0.30,p=0.1)无显著差异。

解释-总的来说,骨水泥固定 TKR 具有更大比例的极好 OKS 评分和更低比例的较差评分,且在所有年龄组中均如此。然而,绝对差异较小,低于最小临床重要差异,这两种固定类型都是可接受的。目前,绝大多数 TKR 采用骨水泥固定,本研究结果表明这是合适的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee7/8815428/46ab5531fed7/ActaO-93-896-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee7/8815428/4fb0450e20ce/ActaO-93-896-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee7/8815428/6f23fc687745/ActaO-93-896-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee7/8815428/025ab67c9030/ActaO-93-896-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee7/8815428/46ab5531fed7/ActaO-93-896-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee7/8815428/4fb0450e20ce/ActaO-93-896-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee7/8815428/6f23fc687745/ActaO-93-896-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee7/8815428/025ab67c9030/ActaO-93-896-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee7/8815428/46ab5531fed7/ActaO-93-896-g004.jpg

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