Georgakopoulou Vasiliki Epameinondas, Zygouris Eleftherios, Damaskos Christos, Pierrakou Aikaterini, Papalexis Petros, Garmpis Nikolaos, Aravantinou-Fatorou Aikaterini, Chlapoutakis Serafeim, Diamantis Evangelos, Nikokiris Christos, Gkoufa Aikaterini, Sklapani Pagona, Trakas Nikolaos, Janinis Jim, Spandidos Demetrios A, Dahabreh Jubrail
Pulmonology Department, Laiko General Hospital, Athens 11527, Greece.
Oncology Department, Athens Medical Group, Athens 15125, Greece.
Mol Clin Oncol. 2022 Feb;16(2):31. doi: 10.3892/mco.2021.2464. Epub 2021 Dec 14.
Lung carcinoid tumor is a type of neuroendocrine tumor, which is subdivided into typical carcinoid (TC) and atypical carcinoid (AT), based on the rate of mitosis and the presence of necrosis. Several prognostic factors for lung carcinoids have been reported in the literature, including the type, Ki67 index, stage, chemotherapy and radiation therapy. In the present study, 108 cases with resected carcinoid lung tumors were enrolled and the expression of CD56, thyroid transcription factor 1, synaptophysin, carcinoembryonic antigen, epithelial membrane antigen and neuron-specific enolase (NSE) in the resected tissue specimens was immunohistochemically analyzed. Patients with positive staining for NSE had an unfavorable survival prognosis compared with patients with negative staining for NSE (137.2 vs. 150.0 months, P=0.044). According to univariate analysis, none of the above immunohistochemistry markers was associated with survival, and according to multivariate analysis, NSE was an independent influencing factor for survival inpatients with AT (P=0.046) and furthermore, the stage was an independent factor of survival in patients with TC (P=0.005).
肺类癌肿瘤是一种神经内分泌肿瘤，根据有丝分裂率和坏死情况可细分为典型类癌（TC）和非典型类癌（AT）。文献中已报道了几种肺类癌的预后因素，包括类型、Ki67指数、分期、化疗和放疗。在本研究中，纳入了108例切除的类癌肺肿瘤患者，并对切除组织标本中CD56、甲状腺转录因子1、突触素、癌胚抗原、上皮膜抗原和神经元特异性烯醇化酶（NSE）的表达进行了免疫组化分析。与NSE染色阴性的患者相比，NSE染色阳性的患者生存预后较差（137.2个月对150.0个月，P = 0.044）。单因素分析显示，上述免疫组化标志物均与生存无关，多因素分析显示，NSE是AT患者生存的独立影响因素（P = 0.046），此外，分期是TC患者生存的独立因素（P = 0.
