Patel Roshni, Koran Kansas, Call Mark, Schnee Amanda
Prisma Health Infectious Disease Specialists, 890 West Faris Road, Suite 520, Greenville, SC 29605, USA.
IDCases. 2021 Dec 16;27:e01366. doi: 10.1016/j.idcr.2021.e01366. eCollection 2022.
endocarditis is often an elusive diagnosis, usually derived from evaluating multiple laboratory tests and assessment of presenting symptoms. Herein we describe a case of native mitral valve endocarditis with an initial presentation of volume overload and renal failure. The organism is tedious to isolate from culture medium, causing most diagnoses to be delayed. Due to the destructive nature of endocarditis, the need for rapid identification remains prudent. This therefore creates an opportunity for Next Generation Sequencing (NGS) to be used. We further summarize the varied presentations that may be associated with endocarditis, and hope that this will heighten the clinicians' awareness of this entity when presented with acute onset renal failure and culture negative vegetations.
心内膜炎常常是一种难以确诊的疾病，通常需要综合评估多项实验室检查结果及对现有症状进行评估才能得出诊断。在此，我们描述一例原发性二尖瓣心内膜炎病例，其最初表现为容量负荷过重和肾衰竭。该病原体很难从培养基中分离出来，导致大多数诊断被延误。由于心内膜炎具有破坏性，因此仍需谨慎地进行快速鉴定。这就为使用下一代测序（NGS）技术创造了机会。我们进一步总结了可能与心内膜炎相关的各种表现形式，希望这能提高临床医生在面对急性肾衰竭和血培养阴性的赘生物时对该疾病的认识。
