Markowicz S, Siwicki J K, Steffen J A
Arch Immunol Ther Exp (Warsz). 1987;35(1):11-21.
Both TG and TnonG subpopulations from human peripheral blood were found to secrete helper and suppressor factors for the PHA-induced T cell proliferative response. The TnonG subpopulation contained cells which were both able to secrete helper factor and to respond by proliferation, whereas in the TG subpopulation cells with a proliferative potential could not be conclusively demonstrated. Suppressor and helper activities in TG and TnonG culture supernatants displayed a different time kinetics and were influenced by the dose of mitogen in test cultures.
研究发现，来自人外周血的TG和TnonG亚群均可分泌促进PHA诱导的T细胞增殖反应的辅助因子和抑制因子。TnonG亚群包含既能分泌辅助因子又能通过增殖作出反应的细胞，而在TG亚群中，具有增殖潜力的细胞尚未得到确凿证实。TG和TnonG培养上清液中的抑制和辅助活性呈现出不同的时间动力学，并且受测试培养物中促有丝分裂原剂量的影响。
