McMurray D N, Bartow R A, Mintzer C L
Department of Medical Microbiology and Immunology, College of Medicine, Texas A&M University, College Station 77843.
Infect Immun. 1990 Feb;58(2):563-5. doi: 10.1128/iai.58.2.563-565.1990.
Inbred, strain 2 guinea pigs were given isocaloric diets containing either 30% (control diet) or 10% (low-protein diet) ovalbumin and infected 4 weeks later by the respiratory route with virulent Mycobacterium tuberculosis. By using an Fc receptor rosette assay, the proportions of T lymphocytes bearing Fc receptors for immunoglobulin G (T gamma cells) or immunoglobulin M (T mu cells) were quantified in blood and lymphoid tissues taken postinfection. A significant elevation in the proportion of the putative suppressor T subset (T gamma) in the blood of protein-deprived guinea pigs was observed at all intervals postinfection. Conversely, the levels of the putative helper T subset (T mu) in the bronchotracheal lymph nodes draining the site of virulent infection in malnourished animals were significantly reduced. Diet did not influence T gamma or T mu cells in the spleens. Diet-induced loss of purified protein derivative-specific T-cell functions in tuberculosis may be associated with alterations in the proportions of or the balances between T gamma and T mu subsets.
将近交2系豚鼠给予含30%（对照饮食）或10%（低蛋白饮食）卵清蛋白的等热量饮食，4周后经呼吸道感染强毒结核分枝杆菌。通过使用Fc受体花环试验，对感染后采集的血液和淋巴组织中携带免疫球蛋白G的Fc受体的T淋巴细胞（Tγ细胞）或免疫球蛋白M的Fc受体的T淋巴细胞（Tμ细胞）的比例进行定量。在感染后的所有时间段，均观察到蛋白质缺乏豚鼠血液中假定的抑制性T亚群（Tγ）比例显著升高。相反，营养不良动物中引流强毒感染部位的气管支气管淋巴结中假定的辅助性T亚群（Tμ）水平显著降低。饮食对脾脏中的Tγ或Tμ细胞没有影响。饮食诱导的结核病中纯化蛋白衍生物特异性T细胞功能丧失可能与Tγ和Tμ亚群比例的改变或平衡有关。
