Furukawa Y, Ohta M, Miura Y, Saito M
Biochem Biophys Res Commun. 1987 Aug 31;147(1):39-46. doi: 10.1016/s0006-291x(87)80084-0.
Interleukin-1 (IL-1) enhances the growth of human monocytic leukemia cell line JOSK-I cells, which were recently established in our laboratory and which were demonstrated to produce a high level of IL-1 constitutively, in liquid as well as semisolid culture systems. Concomitantly, IL-1 stimulated the prostaglandin E2 synthesis and nitroblue tetrazolium dye-reducing capacity of JOSK-I cells. This indicates that IL-1 may act as autocrine growth factor for monocytes, and also suggests the possibility that this autocrine stimulation may play an important role in the pathophysiology of monocytic leukemia in vivo.
白细胞介素-1（IL-1）可促进人单核细胞白血病细胞系JOSK-I细胞的生长，该细胞系是我们实验室最近建立的，已证明其在液体培养系统和半固体培养系统中均可组成性地产生高水平的IL-1。同时，IL-1刺激了JOSK-I细胞的前列腺素E2合成和硝基蓝四氮唑染料还原能力。这表明IL-1可能作为单核细胞的自分泌生长因子，也提示这种自分泌刺激可能在体内单核细胞白血病的病理生理学中起重要作用。
