UMR_A1131 Université de Strasbourg-INRAE, 68000 Colmar, France.
Viruses. 2023 Sep 26;15(10):2000. doi: 10.3390/v15102000.
Plant proteins with domains rich in leucine repeats play important roles in detecting pathogens and triggering defense reactions, both at the cellular surface for pattern-triggered immunity and in the cell to ensure effector-triggered immunity. As intracellular parasites, viruses are mostly detected intracellularly by proteins with a nucleotide binding site and leucine-rich repeats but receptor-like kinases with leucine-rich repeats, known to localize at the cell surface, have also been involved in response to viruses. In the present review we report on the progress that has been achieved in the last decade on the role of these leucine-rich proteins in antiviral immunity, with a special focus on our current understanding of the hypersensitive response.
富含亮氨酸重复序列的植物蛋白在检测病原体和触发防御反应方面发挥着重要作用，既能在细胞表面触发模式触发免疫，也能在细胞内确保效应物触发免疫。作为细胞内寄生虫，病毒主要通过具有核苷酸结合位点和富含亮氨酸重复序列的蛋白在细胞内被检测到，但已知定位于细胞表面的富含亮氨酸重复序列的类受体激酶也参与了对病毒的反应。在本综述中，我们报告了过去十年中这些富含亮氨酸的蛋白在抗病毒免疫中的作用所取得的进展，特别关注我们对过敏反应的理解。
