Mak C P, Wu Y C, Chang C H, Hsieh R P, Lü Y C
Department of Dermatology, National Taiwan University Hospital, Taipei, ROC.
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1987 May;20(2):95-103.
The current hypothesis on the pathogenesis of alopecia areata is immunologically mediated, yet no conclusive data has been documented. To clarify the changes in various phases of disease evolution, analysis of T lymphocyte subpopulations was carried out in the peripheral blood of 34 patients and 27 healthy normal subjects by means of OKT-3, OKT-4, OKT-8 and Ia1 monoclonal antibodies. Study of lymphocyte proliferation in response to various mitogens was further carried out in 27 patients and 25 healthy normal subjects. Significant predominance (p less than 0.01) of OKT-8 positive (cytotoxic/suppressor) cells and diminution (p less than 0.01) of Ia1 positive cells were noted in the whole alopecia group and in various subgroups of disease evolution. Since diminution (p less than 0.05) of OKT-4 positive (inducer/helper) cells was also noted in the stable phase, it was postulated that these activated T cells migrated from circulation to the local site of primary event. Hence, it was evident that the predominance of cytotoxic/suppressor cells was a relative change, and the role of inducer/helper cells in the pathogenesis was implicated. No enhancement of lymphocyte proliferation was observed.
目前关于斑秃发病机制的假说是免疫介导的，但尚无确凿数据记录。为阐明疾病演变各阶段的变化，采用OKT - 3、OKT - 4、OKT - 8和Ia1单克隆抗体，对34例患者和27名健康正常受试者的外周血进行了T淋巴细胞亚群分析。进一步对27例患者和25名健康正常受试者进行了淋巴细胞对各种有丝分裂原反应的增殖研究。在整个斑秃组和疾病演变的各个亚组中，均发现OKT - 8阳性（细胞毒性/抑制性）细胞显著占优势（p < 0.01），Ia1阳性细胞减少（p < 0.01）。由于在稳定期也发现OKT - 4阳性（诱导/辅助性）细胞减少（p < 0.05），推测这些活化的T细胞从循环迁移至原发事件的局部部位。因此，很明显细胞毒性/抑制性细胞的优势是一种相对变化，诱导/辅助性细胞在发病机制中的作用也受到牵连。未观察到淋巴细胞增殖增强。
