Braga P C, Biella G, Tiengo M
Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Italy.
Drugs Exp Clin Res. 1987;13(7):389-98.
The antinociceptive action of tenoxicam, a new non-steroidal anti-inflammatory drug, has been investigated by exploring the spontaneous and evoked electrophysiological patterns of firing of thalamic neurons in arthritic rats. A marked decrease in the firing activity evoked by ankle mobilization has been found to be present at doses of tenoxicam of 0.6 mg/kg i.v. A similar effect is obtainable with aspirin (as reference drug) but with doses of 54 mg/kg i.v. On studying the effects of increasing doses of tenoxicam a progressively longer time-course inhibition has been found and the analysis confirmed a linear correlation. Findings are discussed postulating that the final antinociceptive effect of tenoxicam can be correlated with its anti-inflammatory activity.
通过研究关节炎大鼠丘脑神经元自发放电和诱发电生理放电模式，对新型非甾体抗炎药替诺昔康的抗伤害感受作用进行了研究。已发现静脉注射0.6mg/kg替诺昔康剂量时，踝关节活动诱发的放电活动显著减少。阿司匹林（作为参比药物）静脉注射54mg/kg剂量时可获得类似效果。在研究替诺昔康递增剂量的作用时，发现抑制作用的时程逐渐延长，分析证实存在线性相关性。对研究结果进行了讨论，推测替诺昔康的最终抗伤害感受作用可能与其抗炎活性相关。
